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• W2471302473 abstract "No AccessJournal of UrologyPediatric Articles1 Oct 1990Nuclear Morphometry as a Predictor of Response to Therapy in Wilms Tumor: A Preliminary Report A.W. Partin, A.C. Walsh, J.I. Epstein, B.G. Leventhal, and J.P. Gearhart A.W. PartinA.W. Partin More articles by this author , A.C. WalshA.C. Walsh More articles by this author , J.I. EpsteinJ.I. Epstein More articles by this author , B.G. LeventhalB.G. Leventhal More articles by this author , and J.P. GearhartJ.P. Gearhart More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39629-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Present therapy in Wilms tumor is based upon prognosis. Current trends suggest less intensive chemotherapy and/or radiation therapy for children with favorable histological disease who are considered at low risk for recurrence and increasing the amount of therapy for those with unfavorable histological tumors who are at high risk for recurrence. Currently, pathological stage and histological appearance are used to predict prognosis. We tested a new approach. Histological sections of surgical specimens were obtained from 9 children treated for unilateral Wilms tumor. All patients had favorable histological disease, and received postoperative chemotherapy and/or radiotherapy. These specimens were evaluated by nuclear morphometry with the Hopkins Morphometry System to determine if nuclear shape descriptors could distinguish children who responded to therapy from those whose tumor recurred. Nuclear roundness, ellipticity, convexity and bending energy accurately separated the groups. Nuclear morphometry may provide useful information that will aid in predicting which children with Wilms tumor will respond to therapy and warrants further investigations. (J. Urol., 144: 952–954, 1990) © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByNeill Borland R, Partin A, Epstein J and Brendler C (2018) The Use of Nuclear Morphometry in Predicting Recurrence of Transitional Cell CarcinomaJournal of Urology, VOL. 149, NO. 2, (272-275), Online publication date: 1-Feb-1993.Leonard M, Partin A, Epstein J, Jeffs R and Gearhart J (2018) Nuclear Morphometry as a Prognostic Indicator for Genitourinary Rhabdomyosarcoma: A Preliminary InvestigationJournal of Urology, VOL. 144, NO. 5, (1222-1226), Online publication date: 1-Nov-1990. Volume 144Issue 4October 1990Page: 952-954 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information A.W. Partin More articles by this author A.C. Walsh More articles by this author J.I. Epstein More articles by this author B.G. Leventhal More articles by this author J.P. Gearhart More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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• W2471302473 title "Nuclear Morphometry as a Predictor of Response to Therapy in Wilms Tumor: A Preliminary Report" @default.
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