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• W2471364117 endingPage "2713" @default.
• W2471364117 startingPage "2705" @default.
• W2471364117 abstract "The cudA gene encodes a nuclear protein that is essential for normal multicellular development. At the slug stage cudA is expressed in the prespore cells and in a sub-region of the prestalk zone. We show that cap site distal promoter sequences direct cudA expression in prespore cells, while proximal sequences direct expression in the prestalk sub-region. The promoter domain that directs prespore-specific transcription consists of a positively acting region, that has the potential to direct expression in all cells within the slug, and a negatively acting region that prevents expression in the prestalk cells. Dd-STATa is the STAT protein that regulates commitment to stalk cell gene expression, where it is known to function as a transcriptional repressor. We show that Dd-STATa binds in vitro to the positively acting part of the prespore domain of the cudA promoter. However, Dd-STATa cannot be utilised for this purpose in vivo, because analysis of a Dd-STATa null mutant strain shows that Dd-STATa is not necessary for cudA transcription in prespore cells. In contrast, the part of the cudA promoter that directs prestalk-specific expression contains a binding site for Dd-STATa that is essential for its biological activity. Dd-STATa appears therefore to serve as a direct activator of cudA transcription in prestalk cells, while a protein with a DNA binding specificity highly related to that of Dd-STATa is utilised to activate cudA transcription in prespore cells." @default.
• W2471364117 created "2016-07-22" @default.
• W2471364117 creator A5005727521 @default.
• W2471364117 creator A5078380114 @default.
• W2471364117 date "2000-06-15" @default.
• W2471364117 modified "2023-10-16" @default.
• W2471364117 title "Analysis of the promoter of the <i>cudA</i> gene reveals novel mechanisms of <i>Dictyostelium</i> cell type differentiation" @default.
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• W2471364117 doi "https://doi.org/10.1242/dev.127.12.2705" @default.
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