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• W2471366587 abstract "Cryopyrin-associated periodic syndromes (CAPS) are caused by mutations in the <i>NLRP3</i> gene leading to overproduction of IL-1β and other NLRP3 inflammasome products. Myeloid-derived suppressor cells (MDSCs) represent a novel innate immune cell subset capable of suppressing T-cell responses. As inflammasome products were previously found to induce MDSCs, we hypothesized that NLRP3 inflammasome-dependent factors induce the generation of MDSCs in CAPS. We studied neutrophilic MDSCs, their clinical relevance, and MDSC-inducing factors in a unique cohort of CAPS patients under anti-IL-1 therapy. Despite anti-IL-1 therapy and low clinical disease activity, CAPS patients showed significantly elevated MDSCs compared to healthy controls. MDSCs were functionally competent, as they suppressed polyclonal T-cell proliferation, as well as Th1 and Th17 responses. In addition, MDSCs decreased monocytic IL-1β secretion. Multiplex assays revealed a distinct pattern of MDSC-inducing cytokines, chemokines, and growth factors. Experimental analyses demonstrated that IL-1 cytokine family members and autoinflammation-associated alarmins differentially induced human MDSCs. Increased MDSCs might represent a novel autologous anti-inflammatory mechanism in autoinflammatory conditions and may serve as a future therapeutic target." @default.
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• W2471366587 date "2016-01-01" @default.
• W2471366587 modified "2023-09-26" @default.
• W2471366587 title "Induction of Myeloid-Derived Suppressor Cells in Cryopyrin-Associated Periodic Syndromes" @default.
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• W2471366587 doi "https://doi.org/10.1159/000446615" @default.
• W2471366587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6743338" @default.
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• W2471366587 hasPublicationYear "2016" @default.
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