FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471436019> ?p ?o ?g. }

• W2471436019 endingPage "F495" @default.
• W2471436019 startingPage "F487" @default.
• W2471436019 abstract "Animal models are indispensable for the study of glomerulonephritis, a group of diseases that destroy kidneys but for which specific therapies do not yet exist. Novel interventions are urgently needed, but their rational design requires suitable in vivo platforms to identify and test new candidates. Animal models can recreate the complex immunologic microenvironments that foster human autoimmunity and nephritis and provide access to tissue compartments not readily examined in patients. Study of rat Heymann nephritis identified fundamental disease mechanisms that ultimately revolutionized our understanding of human membranous nephropathy. Significant species differences in expression of a major target antigen, however, and lack of spontaneous autoimmunity in animals remain roadblocks to full exploitation of preclinical models in this disease. For several glomerulonephritides, humanized models have been developed to circumvent cross-species barriers and to study the effects of human genetic risk variants. Herein we review humanized mouse prototypes that provide fresh insight into mediators of IgA nephropathy and origins of antiglomerular basement membrane nephritis and Goodpasture's disease, as well as a means to test novel therapies for ANCA vasculitis. Additional and refined model systems are needed to mirror the full spectrum of human disease in a genetically diverse population, to facilitate development of patient-specific interventions, to determine the origin of nephritogenic autoimmunity, and to define the role of environmental exposures in disease initiation and relapse." @default.
• W2471436019 created "2016-07-22" @default.
• W2471436019 creator A5006314884 @default.
• W2471436019 date "2016-09-01" @default.
• W2471436019 modified "2023-10-14" @default.
• W2471436019 title "Optimizing the translational value of animal models of glomerulonephritis: insights from recent murine prototypes" @default.
• W2471436019 cites W1484645691 @default.
• W2471436019 cites W1552698000 @default.
• W2471436019 cites W1585554327 @default.
• W2471436019 cites W158579221 @default.
• W2471436019 cites W1822481367 @default.
• W2471436019 cites W185344885 @default.
• W2471436019 cites W1873279641 @default.
• W2471436019 cites W1953831216 @default.
• W2471436019 cites W1968091806 @default.
• W2471436019 cites W1968137793 @default.
• W2471436019 cites W1968598953 @default.
• W2471436019 cites W1970495851 @default.
• W2471436019 cites W1972630878 @default.
• W2471436019 cites W1975602859 @default.
• W2471436019 cites W1978467881 @default.
• W2471436019 cites W1979541272 @default.
• W2471436019 cites W1983344552 @default.
• W2471436019 cites W1986167294 @default.
• W2471436019 cites W1987260357 @default.
• W2471436019 cites W2003120234 @default.
• W2471436019 cites W2007669811 @default.
• W2471436019 cites W2014571143 @default.
• W2471436019 cites W2017797421 @default.
• W2471436019 cites W2023134552 @default.
• W2471436019 cites W2023471150 @default.
• W2471436019 cites W2024260411 @default.
• W2471436019 cites W2027031697 @default.
• W2471436019 cites W2033200533 @default.
• W2471436019 cites W2042487967 @default.
• W2471436019 cites W2042756084 @default.
• W2471436019 cites W2045662685 @default.
• W2471436019 cites W2047093719 @default.
• W2471436019 cites W2048729217 @default.
• W2471436019 cites W2049085096 @default.
• W2471436019 cites W2051150504 @default.
• W2471436019 cites W2061425666 @default.
• W2471436019 cites W2075633094 @default.
• W2471436019 cites W2077190123 @default.
• W2471436019 cites W2080882856 @default.
• W2471436019 cites W2083760961 @default.
• W2471436019 cites W2095967508 @default.
• W2471436019 cites W2097612833 @default.
• W2471436019 cites W2101039659 @default.
• W2471436019 cites W2101758099 @default.
• W2471436019 cites W2104599968 @default.
• W2471436019 cites W2109334393 @default.
• W2471436019 cites W2111285312 @default.
• W2471436019 cites W2111750889 @default.
• W2471436019 cites W2119900188 @default.
• W2471436019 cites W2122595921 @default.
• W2471436019 cites W2123430087 @default.
• W2471436019 cites W2134500017 @default.
• W2471436019 cites W2138353144 @default.
• W2471436019 cites W2141225393 @default.
• W2471436019 cites W2143509920 @default.
• W2471436019 cites W2143558168 @default.
• W2471436019 cites W2143565440 @default.
• W2471436019 cites W2145486852 @default.
• W2471436019 cites W2146854727 @default.
• W2471436019 cites W2148918245 @default.
• W2471436019 cites W2153534142 @default.
• W2471436019 cites W2154713409 @default.
• W2471436019 cites W2158873077 @default.
• W2471436019 cites W2160167050 @default.
• W2471436019 cites W2160578795 @default.
• W2471436019 cites W2163169095 @default.
• W2471436019 cites W2164249826 @default.
• W2471436019 cites W2166822765 @default.
• W2471436019 cites W2166885924 @default.
• W2471436019 cites W2167807799 @default.
• W2471436019 cites W2169832897 @default.
• W2471436019 cites W2395598045 @default.
• W2471436019 cites W2405183840 @default.
• W2471436019 cites W3143678149 @default.
• W2471436019 cites W4233885503 @default.
• W2471436019 cites W4239292067 @default.
• W2471436019 doi "https://doi.org/10.1152/ajprenal.00275.2016" @default.
• W2471436019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5142166" @default.
• W2471436019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27335377" @default.
• W2471436019 hasPublicationYear "2016" @default.
• W2471436019 type Work @default.
• W2471436019 sameAs 2471436019 @default.
• W2471436019 citedByCount "8" @default.
• W2471436019 countsByYear W24714360192018 @default.
• W2471436019 countsByYear W24714360192019 @default.
• W2471436019 countsByYear W24714360192020 @default.
• W2471436019 countsByYear W24714360192022 @default.
• W2471436019 crossrefType "journal-article" @default.
• W2471436019 hasAuthorship W2471436019A5006314884 @default.
• W2471436019 hasBestOaLocation W24714360191 @default.
• W2471436019 hasConcept C126322002 @default.
• W2471436019 hasConcept C134018914 @default.

• next