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- W2471483670 abstract "The effects of synaptic use and disuse on cellular biochemistry have wide implications in neurobiology. This aspect of synaptic function has been examined in most detail at the neuromuscular junction, particularly with respect to the regulation of postjunctional sensitivity. Inhibition of neuromuscular transmission by denervation, chronic receptor blockade or chronic conduction block in the motor neurons produces an increase in the number of extrajunctional acetylcholine receptors which results in the phenomenon originally termed “denervation” supersensitivity (see Zigmond and Bowers, 1981, for a recent review). Lomo and Rosenthal (1972) found that the development of this supersensitivity could be prevented or reversed by direct electrical stimulation of the muscle at frequencies within the physiological range. These studies and others have led to the view that the synthesis and insertion of extrajunctional acetylcholine receptors is normally inhibited by the activity of the muscle cells, which in turn is regulated by the activity of motor neurons." @default.
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- W2471483670 date "1981-01-01" @default.
- W2471483670 modified "2023-09-24" @default.
- W2471483670 title "Investigations of the relationship between changes in neural activity and changes in tissue biochemistry: some criteria and the example of serotonin N-acetyltransferase" @default.
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- W2471483670 doi "https://doi.org/10.1007/978-1-349-06276-8_78" @default.
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