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• W2471487323 abstract "Crohn’s disease and ulcerative colitis, the two major forms of idiopathic inflammatory bowel disease (IBD), are thought to occur through a loss of intestinal barrier leading to an inappropriate immune response toward intestinal microbiota. While genome-wide association studies (GWAS) have provided much information about susceptibility loci associated with these diseases, the etiology of IBD is still unknown. Metabolomic analysis allows for the comprehensive measurement of multiple small molecule metabolites in biological samples. During the past decade, metabolomic techniques have yielded novel and potentially important findings, revealing insight into metabolic perturbations associated with these diseases. This chapter provides metabolomic methodologies describing a nuclear magnetic resonance (NMR)-based non-targeted approach that has been utilized to make important contributions toward a better understanding of IBD." @default.
• W2471487323 created "2016-07-22" @default.
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• W2471487323 date "2016-01-01" @default.
• W2471487323 modified "2023-09-26" @default.
• W2471487323 title "NMR-Based Metabolomic Analysis of Normal and Inflamed Gut" @default.
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• W2471487323 doi "https://doi.org/10.1007/978-1-4939-3603-8_8" @default.
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