Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471488369> ?p ?o ?g. }
- W2471488369 endingPage "278" @default.
- W2471488369 startingPage "266" @default.
- W2471488369 abstract "Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years). Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86×10(-8)) and rs872256 during puberty (P=8.67×10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P<5×10(-3). Using a P value threshold of <5×10(-3), we found some overlap in variants across the different age epochs within our study and between several single-nucleotide polymorphisms in any of the 3 epochs and adult BP-related single-nucleotide polymorphisms.Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects." @default.
- W2471488369 created "2016-07-22" @default.
- W2471488369 creator A5003157959 @default.
- W2471488369 creator A5005865871 @default.
- W2471488369 creator A5015920377 @default.
- W2471488369 creator A5017009749 @default.
- W2471488369 creator A5024182885 @default.
- W2471488369 creator A5024230104 @default.
- W2471488369 creator A5027927685 @default.
- W2471488369 creator A5029024758 @default.
- W2471488369 creator A5031530236 @default.
- W2471488369 creator A5034611264 @default.
- W2471488369 creator A5035900967 @default.
- W2471488369 creator A5036671564 @default.
- W2471488369 creator A5039611937 @default.
- W2471488369 creator A5043163204 @default.
- W2471488369 creator A5043513022 @default.
- W2471488369 creator A5044031753 @default.
- W2471488369 creator A5045622178 @default.
- W2471488369 creator A5045767788 @default.
- W2471488369 creator A5050844526 @default.
- W2471488369 creator A5052245802 @default.
- W2471488369 creator A5054791973 @default.
- W2471488369 creator A5058437769 @default.
- W2471488369 creator A5064118768 @default.
- W2471488369 creator A5064383725 @default.
- W2471488369 creator A5066194292 @default.
- W2471488369 creator A5067155820 @default.
- W2471488369 creator A5067224066 @default.
- W2471488369 creator A5067420890 @default.
- W2471488369 creator A5067599248 @default.
- W2471488369 creator A5070337737 @default.
- W2471488369 creator A5074877417 @default.
- W2471488369 creator A5075624440 @default.
- W2471488369 creator A5076433645 @default.
- W2471488369 creator A5076916676 @default.
- W2471488369 creator A5081737623 @default.
- W2471488369 creator A5081986241 @default.
- W2471488369 creator A5089303412 @default.
- W2471488369 creator A5090277687 @default.
- W2471488369 date "2016-06-01" @default.
- W2471488369 modified "2023-10-16" @default.
- W2471488369 title "International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents" @default.
- W2471488369 cites W1515784545 @default.
- W2471488369 cites W1968176785 @default.
- W2471488369 cites W1974904303 @default.
- W2471488369 cites W1976308716 @default.
- W2471488369 cites W1981946201 @default.
- W2471488369 cites W1983408225 @default.
- W2471488369 cites W1985614519 @default.
- W2471488369 cites W1990041550 @default.
- W2471488369 cites W1991015699 @default.
- W2471488369 cites W1996537764 @default.
- W2471488369 cites W1998275162 @default.
- W2471488369 cites W2001629081 @default.
- W2471488369 cites W2034690369 @default.
- W2471488369 cites W2035631895 @default.
- W2471488369 cites W2035650854 @default.
- W2471488369 cites W2037580369 @default.
- W2471488369 cites W2038074875 @default.
- W2471488369 cites W2042257745 @default.
- W2471488369 cites W2044707173 @default.
- W2471488369 cites W2058315001 @default.
- W2471488369 cites W2058368478 @default.
- W2471488369 cites W2064328378 @default.
- W2471488369 cites W2066666285 @default.
- W2471488369 cites W2067382823 @default.
- W2471488369 cites W2078845557 @default.
- W2471488369 cites W2080580325 @default.
- W2471488369 cites W2090661178 @default.
- W2471488369 cites W2091853620 @default.
- W2471488369 cites W2097572487 @default.
- W2471488369 cites W2101605059 @default.
- W2471488369 cites W2102622802 @default.
- W2471488369 cites W2102984318 @default.
- W2471488369 cites W2104115143 @default.
- W2471488369 cites W2105306382 @default.
- W2471488369 cites W2109989539 @default.
- W2471488369 cites W2110085945 @default.
- W2471488369 cites W2110227655 @default.
- W2471488369 cites W2110924846 @default.
- W2471488369 cites W2114901030 @default.
- W2471488369 cites W2120798274 @default.
- W2471488369 cites W2125523997 @default.
- W2471488369 cites W2129254992 @default.
- W2471488369 cites W2133520037 @default.
- W2471488369 cites W2133804898 @default.
- W2471488369 cites W2134270369 @default.
- W2471488369 cites W2135185355 @default.
- W2471488369 cites W2135528729 @default.
- W2471488369 cites W2138358802 @default.
- W2471488369 cites W2142660190 @default.
- W2471488369 cites W2149709747 @default.
- W2471488369 cites W2163013660 @default.
- W2471488369 cites W2164265846 @default.
- W2471488369 cites W2167053513 @default.
- W2471488369 cites W2259938310 @default.
- W2471488369 cites W2608915729 @default.