Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471497488> ?p ?o ?g. }
- W2471497488 abstract "A BSTRACT Thrombolytic agents maybeuseful in acutepulmonary embolism, buttheiroptimal dosage remains uncertain. We haveexamined therelative efficacyofheparin anddifferent dosesofstreptokinase, either alone orincombination, inacuteexperimental pulmonary embolism. A standardized massive embolus ofautologous bloodclotincorporating canine[1I]fibrinogen wasgiven to40dogs; thedegree ofresolutionafter 24hwasquantitated bymeasuring theradioactivity inthelungs andwascompared withdetailed postmortem observations. Theamountofresidual embolus was49%incontrol animals, 28% after heparin (200U/kgloading dose and800U/kg/24 h maintenance dose), and6% after highdosestreptokinase (250,000 U loading doseand 100,000 U/hmaintenance dose); itwas31%after low dosestreptokinase (25,000 U loading doseand10,000 U/hmaintenance dose), 7% afterlowdosestreptokinase withheparin, 14%after verylowdosestreptokinase (5,000 U/hwithout aloading dose) withheparin, and9% after short coursestreptokinase (250,000 U loading doseandnomaintenance dose) withheparin. Thecombination ofheparin andlowdoses orbrief courses ofstreptokinase appeared tobesynergistic and produced asmuchresolution asdidstandard highdose streptokinase alone. Theenhanced resolution ofpulmonaryemboli inheparin-treated animals mayhavebeen duetotheprevention byheparin offurther deposition offibrin ontheembolus. Itappears thatdosage regimensofthrombolytic therapy other thanthose incurrentusemaybeworthy ofclinical examination." @default.
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- W2471497488 date "1974-01-01" @default.
- W2471497488 modified "2023-09-23" @default.
- W2471497488 title "Resolution ofExperimental Pulmonary Emboliwith Heparin andStreptokinase in Different DosageRegimens" @default.
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