FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471570383> ?p ?o ?g. }

• W2471570383 endingPage "68" @default.
• W2471570383 startingPage "58" @default.
• W2471570383 abstract "Liver fibrosis refers to a reversible wound healing process response to chronic liver injuries. Activation of hepatic stellate cells (HSCs) is closely correlated with the development of liver fibrosis. Histone deacetylases(HDACs) determine the acetylation levels of core histones to modulate expression of genes. To demonstrate the link between HDACs and liver fibrosis, CCl4-induced mouse liver fibrosis model and its spontaneous reversal model were established. Results of the current study demonstrated that deregulation of liver HDACs may involved in the development of liver fibrosis. Among 11 HDACs tested in our study (Class I, II, and IV HDACs), expression of HDAC2 was maximally increased in CCl4-induced fibrotic livers but decreased after spontaneous recovery. Moreover, expression of HDAC2 was elevated in human liver fibrotic tissues. In this regard, the potential role of HDAC2 in liver fibrosis was further evaluated. Our results showed that administration of HSC-T6 cells with transforming growth factor-beta1 (TGF-β1) resulted in an increase of HDAC2 protein expression in dose- and time-dependent manners. Moreover, HDAC2 deficiency inhibited HSC-T6 cell proliferation and activation induced by TGF-β1. More importantly, the present study showed HDAC2 may regulate HSCs activation by suppressing expression of Smad7, which is a negative modulator in HSCs activation and liver fibrosis. Collectively, these observations revealed that HDAC2 may play a pivotal role in HSCs activation and liver fibrosis while deregulation of HDACs may serve as a novel mechanism underlying liver fibrosis." @default.
• W2471570383 created "2016-07-22" @default.
• W2471570383 creator A5019018136 @default.
• W2471570383 creator A5025751238 @default.
• W2471570383 creator A5027835055 @default.
• W2471570383 creator A5033281701 @default.
• W2471570383 creator A5038545320 @default.
• W2471570383 creator A5049692788 @default.
• W2471570383 creator A5054536226 @default.
• W2471570383 creator A5061349095 @default.
• W2471570383 creator A5091210737 @default.
• W2471570383 date "2016-09-01" @default.
• W2471570383 modified "2023-10-04" @default.
• W2471570383 title "Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis" @default.
• W2471570383 cites W1651186680 @default.
• W2471570383 cites W1831059025 @default.
• W2471570383 cites W1863017422 @default.
• W2471570383 cites W1888687424 @default.
• W2471570383 cites W1906235443 @default.
• W2471570383 cites W1976059452 @default.
• W2471570383 cites W1982484050 @default.
• W2471570383 cites W1982577475 @default.
• W2471570383 cites W1992195166 @default.
• W2471570383 cites W2012631080 @default.
• W2471570383 cites W2015849705 @default.
• W2471570383 cites W2022836778 @default.
• W2471570383 cites W2028806642 @default.
• W2471570383 cites W2033773458 @default.
• W2471570383 cites W2040059531 @default.
• W2471570383 cites W2043355784 @default.
• W2471570383 cites W2049736951 @default.
• W2471570383 cites W2051152566 @default.
• W2471570383 cites W2051329702 @default.
• W2471570383 cites W2057095258 @default.
• W2471570383 cites W2057438237 @default.
• W2471570383 cites W2064699135 @default.
• W2471570383 cites W2065764124 @default.
• W2471570383 cites W2067978765 @default.
• W2471570383 cites W2070897057 @default.
• W2471570383 cites W2073939345 @default.
• W2471570383 cites W2075290880 @default.
• W2471570383 cites W2079605182 @default.
• W2471570383 cites W2082579037 @default.
• W2471570383 cites W2089076289 @default.
• W2471570383 cites W2093165417 @default.
• W2471570383 cites W2098421919 @default.
• W2471570383 cites W2104193042 @default.
• W2471570383 cites W2109023646 @default.
• W2471570383 cites W2114628121 @default.
• W2471570383 cites W2118964113 @default.
• W2471570383 cites W2124258829 @default.
• W2471570383 cites W2126632735 @default.
• W2471570383 cites W2129933068 @default.
• W2471570383 cites W2137562588 @default.
• W2471570383 cites W2142988890 @default.
• W2471570383 cites W2147934487 @default.
• W2471570383 cites W2148718757 @default.
• W2471570383 cites W2170029684 @default.
• W2471570383 cites W2323637528 @default.
• W2471570383 cites W4246228784 @default.
• W2471570383 cites W4255712601 @default.
• W2471570383 doi "https://doi.org/10.1016/j.taap.2016.07.003" @default.
• W2471570383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27396813" @default.
• W2471570383 hasPublicationYear "2016" @default.
• W2471570383 type Work @default.
• W2471570383 sameAs 2471570383 @default.
• W2471570383 citedByCount "23" @default.
• W2471570383 countsByYear W24715703832017 @default.
• W2471570383 countsByYear W24715703832018 @default.
• W2471570383 countsByYear W24715703832019 @default.
• W2471570383 countsByYear W24715703832020 @default.
• W2471570383 countsByYear W24715703832021 @default.
• W2471570383 countsByYear W24715703832022 @default.
• W2471570383 countsByYear W24715703832023 @default.
• W2471570383 crossrefType "journal-article" @default.
• W2471570383 hasAuthorship W2471570383A5019018136 @default.
• W2471570383 hasAuthorship W2471570383A5025751238 @default.
• W2471570383 hasAuthorship W2471570383A5027835055 @default.
• W2471570383 hasAuthorship W2471570383A5033281701 @default.
• W2471570383 hasAuthorship W2471570383A5038545320 @default.
• W2471570383 hasAuthorship W2471570383A5049692788 @default.
• W2471570383 hasAuthorship W2471570383A5054536226 @default.
• W2471570383 hasAuthorship W2471570383A5061349095 @default.
• W2471570383 hasAuthorship W2471570383A5091210737 @default.
• W2471570383 hasConcept C104317684 @default.
• W2471570383 hasConcept C118131993 @default.
• W2471570383 hasConcept C119157956 @default.
• W2471570383 hasConcept C126322002 @default.
• W2471570383 hasConcept C134018914 @default.
• W2471570383 hasConcept C176891718 @default.
• W2471570383 hasConcept C2778305200 @default.
• W2471570383 hasConcept C2780559512 @default.
• W2471570383 hasConcept C502942594 @default.
• W2471570383 hasConcept C55493867 @default.
• W2471570383 hasConcept C64927066 @default.
• W2471570383 hasConcept C71723506 @default.
• W2471570383 hasConcept C71924100 @default.
• W2471570383 hasConcept C86803240 @default.

• next