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- W2471580532 abstract "Aim: To synthesize and characterize cost-efficient polyethylenimine-entrapped gold nanoparticles loaded with gadolinium (Gd@Au PENPs) for dual-mode computed tomography (CT)/magnetic resonance (MR) imaging applications. Materials & methods: PEGylated PEI modified with gadolinium (Gd) chelator (DOTA) was used as a template to synthesize the Gd@Au PENPs and the particles were well characterized in terms of their physicochemical properties, cytotoxicity and performances in CT and MR imaging in vitro and in vivo. Results: The formed Gd@Au PENPs with low cytotoxicity can be used as a highly efficient contrast agent for dual-mode CT/MR imaging of blood pool and major organs of animals. Conclusion: The designed Gd@Au PENPs may be used as a versatile nanoplatform for dual-mode CT/MR imaging of different biological systems." @default.
- W2471580532 created "2016-07-22" @default.
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- W2471580532 date "2016-07-01" @default.
- W2471580532 modified "2023-09-24" @default.
- W2471580532 title "PEGylated polyethylenimine-entrapped gold nanoparticles loaded with gadolinium for dual-mode CT/MR imaging applications" @default.
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- W2471580532 doi "https://doi.org/10.2217/nnm-2016-0093" @default.
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