Matches in SemOpenAlex for { <https://semopenalex.org/work/W247160020> ?p ?o ?g. }
- W247160020 endingPage "100" @default.
- W247160020 startingPage "92" @default.
- W247160020 abstract "Microcystin-LR (MC-LR), a potent hepatotoxin produced by certain bloom-forming cyanobacteria, covalently binds to serine/threonine protein phosphatases and acts as an efficient inhibitor of this group of enzymes. MC-LR induces oxidative stress and the unfolded protein response in multiple cell types, leading to apoptosis through the mitochondrial and endoplasmic reticulum pathways. Histologic lesions of acute MC-LR toxicosis exhibit membrane blebbing, cell rounding and dissociation, indicating that this toxin may exert hepatotoxic effects by causing cytoskeletal disruption. Both in vivo and in vitro studies have revealed that exposure of human, mouse, or rat hepatocytes to MC-LR induces the rearrangement or collapse of the three components of the cytoskeleton. In addition, multiple cytoskeletal and cytoskeleton-associated proteins have been found to be affected by MC-LR. This review summarizes the increasing information in the literature pertaining to the molecular mechanisms of MC-LR-induced cytoskeletal disruption and may increase our understanding of its toxicity." @default.
- W247160020 created "2016-06-24" @default.
- W247160020 creator A5032807978 @default.
- W247160020 creator A5062960400 @default.
- W247160020 creator A5065015327 @default.
- W247160020 date "2015-07-01" @default.
- W247160020 modified "2023-10-15" @default.
- W247160020 title "Mechanisms of microcystin-LR-induced cytoskeletal disruption in animal cells" @default.
- W247160020 cites W1496832150 @default.
- W247160020 cites W1582149612 @default.
- W247160020 cites W1582610609 @default.
- W247160020 cites W160446305 @default.
- W247160020 cites W1865957776 @default.
- W247160020 cites W1913117078 @default.
- W247160020 cites W1965830409 @default.
- W247160020 cites W1965831400 @default.
- W247160020 cites W1967858886 @default.
- W247160020 cites W1968534841 @default.
- W247160020 cites W1968627279 @default.
- W247160020 cites W1968714545 @default.
- W247160020 cites W1969048724 @default.
- W247160020 cites W1970207313 @default.
- W247160020 cites W1972366604 @default.
- W247160020 cites W1973122402 @default.
- W247160020 cites W1973210866 @default.
- W247160020 cites W1974882883 @default.
- W247160020 cites W1974923921 @default.
- W247160020 cites W1976576149 @default.
- W247160020 cites W1977139014 @default.
- W247160020 cites W1977532369 @default.
- W247160020 cites W1977599918 @default.
- W247160020 cites W1977712275 @default.
- W247160020 cites W1979378857 @default.
- W247160020 cites W1979985681 @default.
- W247160020 cites W1983225676 @default.
- W247160020 cites W1984245790 @default.
- W247160020 cites W1985041952 @default.
- W247160020 cites W1987474302 @default.
- W247160020 cites W1991958238 @default.
- W247160020 cites W1992361007 @default.
- W247160020 cites W1992813817 @default.
- W247160020 cites W1994260666 @default.
- W247160020 cites W1997054509 @default.
- W247160020 cites W1998366361 @default.
- W247160020 cites W1998921988 @default.
- W247160020 cites W1999793253 @default.
- W247160020 cites W2000810227 @default.
- W247160020 cites W2002389652 @default.
- W247160020 cites W2002680755 @default.
- W247160020 cites W2003762048 @default.
- W247160020 cites W2003991192 @default.
- W247160020 cites W2004256319 @default.
- W247160020 cites W2007403502 @default.
- W247160020 cites W2007648109 @default.
- W247160020 cites W2007935491 @default.
- W247160020 cites W2008715871 @default.
- W247160020 cites W2008981126 @default.
- W247160020 cites W2013752282 @default.
- W247160020 cites W2013902311 @default.
- W247160020 cites W2017404541 @default.
- W247160020 cites W2022587322 @default.
- W247160020 cites W2022607262 @default.
- W247160020 cites W2024996523 @default.
- W247160020 cites W2025511820 @default.
- W247160020 cites W2026492207 @default.
- W247160020 cites W2026572984 @default.
- W247160020 cites W2027575456 @default.
- W247160020 cites W2027903664 @default.
- W247160020 cites W2030524684 @default.
- W247160020 cites W2032308096 @default.
- W247160020 cites W2034286717 @default.
- W247160020 cites W2035047389 @default.
- W247160020 cites W2038136957 @default.
- W247160020 cites W2038638713 @default.
- W247160020 cites W2039252864 @default.
- W247160020 cites W2042695938 @default.
- W247160020 cites W2042903489 @default.
- W247160020 cites W2045086385 @default.
- W247160020 cites W2045377718 @default.
- W247160020 cites W2046476770 @default.
- W247160020 cites W2051611281 @default.
- W247160020 cites W2052057579 @default.
- W247160020 cites W2052176720 @default.
- W247160020 cites W2053167022 @default.
- W247160020 cites W2054334092 @default.
- W247160020 cites W2055263202 @default.
- W247160020 cites W2055313721 @default.
- W247160020 cites W2056074767 @default.
- W247160020 cites W2056972047 @default.
- W247160020 cites W2057257609 @default.
- W247160020 cites W2057579254 @default.
- W247160020 cites W2062918974 @default.
- W247160020 cites W2064248967 @default.
- W247160020 cites W2064543177 @default.
- W247160020 cites W2065813558 @default.
- W247160020 cites W2065856887 @default.
- W247160020 cites W2065933981 @default.
- W247160020 cites W2067129601 @default.