Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471624891> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2471624891 abstract "This study reports significant damage to dendrites (neural information receivers in synapses) in the CA1 stratum radiatum region of the hippocampal due to hyperglycemia. Hyperglycemia is a disorder caused by abnormally high blood glucose levels (> 125 mg/dL) that puts 80% of extremely preterm babies born each year at risk for decreased brain mass, intraventricular hemorrhage, blindness, and possible damage to the hippocampus, which is the area of the brain responsible for memory and spatial reasoning. Fluorescent immunohistochemistry was selected to stain for greater sensitivity of dendrite visualization in tissues of the CA1 stratum radiatum region of the hippocampus from a hyperglycemic rat model. When some tissues stained poorly with the primary antibody anti-beta tubulin, chosen for its structural component of microtubules and critical role in axon growth and maintenance, a small-scale test was developed using the primary antibody microtubule associated protein-2 (MAP2) to isolate the staining problem. Results suggested that MAP2 was more effective in staining. Then, Adobe Photoshop CS6 image analysis was pioneered in the lab to quantify fluorescence from stained dendrites by fluorescence of tagged dendrites in pixels, rather than numbers of dendrites expressed relative to number of neurons (i.e. dendrites/neuron). To eliminate bias, Photoshop CS6 analyses were blinded. Adobe Photoshop CS6 worked well, effectively eliminating the need to manually count dendrites, thus decreasing error and time needed for analysis. Results showed significant damage to dendrites in tissues of the CA1 stratum radiatum region of the hippocampus due to hyperglycemia (p = 0.024). Kirkpatrick G, McFarland A. Food for thought: Long-term effects of hyperglycemia on dendrites in the CA1 region of the hippocampus. Minnesota Academy of Science Journal of Student Research 2015; 3:12-18." @default.
- W2471624891 created "2016-07-22" @default.
- W2471624891 creator A5013498908 @default.
- W2471624891 creator A5076798046 @default.
- W2471624891 date "2015-01-01" @default.
- W2471624891 modified "2023-09-27" @default.
- W2471624891 title "Food for Thought: Long-Term Effects of Hyperglycemia on Dendrites in the CA1 Region of the Hippocampus" @default.
- W2471624891 cites W1535134773 @default.
- W2471624891 cites W1999403853 @default.
- W2471624891 cites W2009904362 @default.
- W2471624891 cites W2029084853 @default.
- W2471624891 cites W2045572016 @default.
- W2471624891 cites W2056038034 @default.
- W2471624891 cites W2065380426 @default.
- W2471624891 cites W2091146826 @default.
- W2471624891 cites W2095502849 @default.
- W2471624891 cites W2108225039 @default.
- W2471624891 cites W2117011266 @default.
- W2471624891 cites W2133211846 @default.
- W2471624891 cites W2145210854 @default.
- W2471624891 cites W2158811812 @default.
- W2471624891 cites W2165201727 @default.
- W2471624891 cites W2399252008 @default.
- W2471624891 cites W2616553828 @default.
- W2471624891 hasPublicationYear "2015" @default.
- W2471624891 type Work @default.
- W2471624891 sameAs 2471624891 @default.
- W2471624891 citedByCount "0" @default.
- W2471624891 crossrefType "journal-article" @default.
- W2471624891 hasAuthorship W2471624891A5013498908 @default.
- W2471624891 hasAuthorship W2471624891A5076798046 @default.
- W2471624891 hasConcept C125473707 @default.
- W2471624891 hasConcept C142724271 @default.
- W2471624891 hasConcept C148762608 @default.
- W2471624891 hasConcept C169760540 @default.
- W2471624891 hasConcept C2524010 @default.
- W2471624891 hasConcept C2779530196 @default.
- W2471624891 hasConcept C2781161787 @default.
- W2471624891 hasConcept C2781294515 @default.
- W2471624891 hasConcept C33923547 @default.
- W2471624891 hasConcept C71924100 @default.
- W2471624891 hasConcept C74864618 @default.
- W2471624891 hasConcept C84248122 @default.
- W2471624891 hasConcept C86803240 @default.
- W2471624891 hasConceptScore W2471624891C125473707 @default.
- W2471624891 hasConceptScore W2471624891C142724271 @default.
- W2471624891 hasConceptScore W2471624891C148762608 @default.
- W2471624891 hasConceptScore W2471624891C169760540 @default.
- W2471624891 hasConceptScore W2471624891C2524010 @default.
- W2471624891 hasConceptScore W2471624891C2779530196 @default.
- W2471624891 hasConceptScore W2471624891C2781161787 @default.
- W2471624891 hasConceptScore W2471624891C2781294515 @default.
- W2471624891 hasConceptScore W2471624891C33923547 @default.
- W2471624891 hasConceptScore W2471624891C71924100 @default.
- W2471624891 hasConceptScore W2471624891C74864618 @default.
- W2471624891 hasConceptScore W2471624891C84248122 @default.
- W2471624891 hasConceptScore W2471624891C86803240 @default.
- W2471624891 hasLocation W24716248911 @default.
- W2471624891 hasOpenAccess W2471624891 @default.
- W2471624891 hasPrimaryLocation W24716248911 @default.
- W2471624891 hasRelatedWork W1602048483 @default.
- W2471624891 hasRelatedWork W1878528568 @default.
- W2471624891 hasRelatedWork W1977865087 @default.
- W2471624891 hasRelatedWork W1987536397 @default.
- W2471624891 hasRelatedWork W2001266454 @default.
- W2471624891 hasRelatedWork W2001856774 @default.
- W2471624891 hasRelatedWork W2006735137 @default.
- W2471624891 hasRelatedWork W2006985248 @default.
- W2471624891 hasRelatedWork W2087570284 @default.
- W2471624891 hasRelatedWork W2089936516 @default.
- W2471624891 hasRelatedWork W2090305142 @default.
- W2471624891 hasRelatedWork W2093130439 @default.
- W2471624891 hasRelatedWork W2148908036 @default.
- W2471624891 hasRelatedWork W2349492254 @default.
- W2471624891 hasRelatedWork W2371069854 @default.
- W2471624891 hasRelatedWork W2391758410 @default.
- W2471624891 hasRelatedWork W2393262694 @default.
- W2471624891 hasRelatedWork W2410459454 @default.
- W2471624891 hasRelatedWork W2412261121 @default.
- W2471624891 hasRelatedWork W2990100387 @default.
- W2471624891 isParatext "false" @default.
- W2471624891 isRetracted "false" @default.
- W2471624891 magId "2471624891" @default.
- W2471624891 workType "article" @default.