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- W2471673498 abstract "Human cyclic hematopoiesis (CH) is a disease characterized by regular 21-day cyclic fluctuations of blood cell counts due to fluctuations in bone marrow cell production. The regular periodicity of the fluctuations suggests a defect in a regulatory feedback control loop. We examined the production of monocyte-derived recruiting activity (MRA) by monocytes and the response to MRA of lymphocytes from three patients with CH. MRA production was normal or increased in patients' monocytes, but granulocyte-macrophage colony-stimulating activity (GM-CSA) production in response to MRA was decreased in lymphocytes from patients with CH (p = 0.005). These data suggest that the regulatory defect in CH may involve defective lymphocyte generation of GM-CSA, resulting in deficient production of mature neutrophils." @default.
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- W2471673498 date "1988-06-01" @default.
- W2471673498 modified "2023-09-23" @default.
- W2471673498 title "Abnormal GM-CSA generation by lymphocytes in patients with cyclic hematopoiesis." @default.
- W2471673498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3286281" @default.
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