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- W2471710040 abstract "The United Nations Population Fund has estimated that the world population in 2050 will reach 10.9 billion [1]. The need for effective contraception is as overwhelming as the statistics. Fortunately, in the western world at least, the notion that contraception is the woman's responsibility is changing. With this change of attitude, along with progress in understanding male reproductive physiology, there has begun an intensive search for a reversible male contraceptive agent [2-5]. LDH-C4 is an isozyme of lactate dehydrogenase (LDH: L-lactate-NAD oxidoreductase EC 1.1.1.27) that is found only in mature testes and spermatozoa of many species with internal fertilization [6]. Its physiological function appears related to metabolic processes that provide energy for motility and survival of spermatozoa [7] and it might be one of the factors responsible for the fertilizing capacity of spermatozoa. For this, LDH-C4 is a target for developing safe, effective and reversible methods for regulating male fertility [8-11]. In this work we studied N-isopropyl oxamate (N-IPO), a new selective inhibitor of the sperm-specific LDH-C4 [12] as a possible inhibitor of sperm motility and fertility in mice, and its prodrug, N-isopropyl oxamate ethyl ester (N-IPOEE), as an approach to the development of a male contraceptive." @default.
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- W2471710040 date "2002-01-01" @default.
- W2471710040 modified "2023-09-26" @default.
- W2471710040 title "The study of N-isopropyl oxamate on sperm motility and fertility, in mice." @default.
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