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- W2471735501 abstract "Abstract Catalytic C–H activation and hydroamination represent two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced waste production. Combining both C–H activation and hydroamination in a cascade process, preferably with a single catalyst, would allow rapid access to valuable nitrogen-containing molecules from readily available building blocks. Here we report a single metal catalyst-based approach for N-heterocycle construction by tandem C–H functionalization and alkene hydroamination. A simple catalyst system of cationic rhodium(I) precursor and phosphine ligand promotes redox-neutral [4+2] annulation between N–H aromatic ketimines and internal alkynes to form multi-substituted 3,4-dihydroisoquinolines (DHIQs) in high chemoselectivity over competing annulation processes, exclusive cis -diastereoselectivity, and distinct regioselectivity for alkyne addition. This study demonstrates the potential of tandem C–H activation and alkene hydrofunctionalization as a general strategy for modular and atom-efficient assembly of six-membered heterocycles with multiple chirality centres." @default.
- W2471735501 created "2016-07-22" @default.
- W2471735501 creator A5032280016 @default.
- W2471735501 creator A5056916918 @default.
- W2471735501 date "2016-06-20" @default.
- W2471735501 modified "2023-10-14" @default.
- W2471735501 title "Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation" @default.
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- W2471735501 doi "https://doi.org/10.1038/ncomms11506" @default.
- W2471735501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4915129" @default.
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- W2471735501 hasPublicationYear "2016" @default.
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