FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W247177564> ?p ?o ?g. }

• W247177564 endingPage "1539" @default.
• W247177564 startingPage "1533" @default.
• W247177564 abstract "No AccessJournal of Urology1 Nov 1993The Influence of Acute Overdistension on Rat Bladder Function and DNA Synthesis Teuvo L.J. Tammela, Robert M. Levin, Frederick C. Monson, Alan J. Wein, and Penelope A. Longhurst Teuvo L.J. TammelaTeuvo L.J. Tammela More articles by this author , Robert M. LevinRobert M. Levin More articles by this author , Frederick C. MonsonFrederick C. Monson More articles by this author , Alan J. WeinAlan J. Wein More articles by this author , and Penelope A. LonghurstPenelope A. Longhurst More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35836-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Prolonged micturition problems are often encountered after long-term bladder overdistension caused by urinary retention. In animal studies, damage to the bladder wall innervation has been found following overdistension. Experimentally, acute overdistension has also been implicated in the pathogenesis of the response to partial outlet obstruction. In the present study we investigated the influence of overdistension on micturition volume and frequency, on in vitro bladder function using the whole bladder model and on 3H-thymidine uptake, localization and DNA synthesis. Overdistension was induced for 3 hours by forced diuresis and balloon obstruction. Another group of rats was catheterized for 3 hours but received no diuretic, nor was the balloon inflated. An additional group of controls was neither anesthetized nor catheterized. Overdistension caused a gradual increase in bladder mass which was maximal at 7 days. During the first 24 hours following overdistension, the frequency of micturition decreased, but normalized thereafter. A progressive decrease in the response to field stimulation was noted between 16 hours and 7 days following overdistension and remained at this level until 21 days. There were, however, no significant differences in the responses to carbachol, ATP and KCl. There was a 30% reduction in the ability of field stimulation to empty the bladder 16 hours after overdistension, but no impairment of the emptying ability of carbachol. Overdistension was followed by a significant increase in 3H-thymidine uptake, which was maximal at 2 days. 3H-thymidine labelling increased rapidly after overdistension and was maximal within 16 hours in the urothelium. In smooth muscle, connective tissue and lamina propria, maximal labelling occurred at 2 days. Catheterization alone caused a mild distension which was associated with a small, but statistically significant, increase in 3H-thymidine incorporation into DNA within 16 hours. The labelling was located primarily in the urothelium. Overdistension causes a proliferative reaction within the bladder wall. Its initial effects occur within the urothelium, and the later involvement of the subendothelial smooth muscle and connective tissue is directly proportional to the degree of bladder distension. Three weeks following overdistension, the bladder’s functional state was not completely recovered, although the urinary bladder was found to have a good capacity to adapt and compensate for the stress-induced changes caused by overdistension. It is, therefore, clear that overdistension may have long-lasting effects on the bladder. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMATSUMOTO S, CHICHESTER P, BRATSLAVSKY G, KOGAN B and LEVIN R (2018) The Functional and Structural Response to Distention of the Rabbit Whole Bladder In VitroJournal of Urology, VOL. 168, NO. 6, (2677-2681), Online publication date: 1-Dec-2002.LONGHURST P (2018) In Vitro Rat Bladder Function After Neonatal EstrogenizationJournal of Urology, VOL. 168, NO. 6, (2695-2699), Online publication date: 1-Dec-2002.OHNISHI N, HORAN P, LEVIN S and LEVIN R (2018) INTERMITTENT CATHETERIZATION LIMITS RABBIT BLADDER DYSFUNCTION IN RESPONSE TO PARTIAL OUTLET OBSTRUCTIONJournal of Urology, VOL. 163, NO. 1, (292-295), Online publication date: 1-Jan-2000.Tammela T, Levin R, Monson F and Longhurst P (2018) Temporal Changes in Rabbit Urinary Bladder Function and DNA Synthesis During Chronic Treatment with FurosemideJournal of Urology, VOL. 151, NO. 2, (503-508), Online publication date: 1-Feb-1994. Volume 150Issue 5 Part 1November 1993Page: 1533-1539 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.Keywordsmuscle contractionbladderratsurinationDNAMetricsAuthor Information Teuvo L.J. Tammela More articles by this author Robert M. Levin More articles by this author Frederick C. Monson More articles by this author Alan J. Wein More articles by this author Penelope A. Longhurst More articles by this author Expand All Advertisement Loading ..." @default.
• W247177564 created "2016-06-24" @default.
• W247177564 creator A5011425417 @default.
• W247177564 creator A5034890219 @default.
• W247177564 creator A5042687042 @default.
• W247177564 creator A5055176143 @default.
• W247177564 creator A5086843638 @default.
• W247177564 date "1993-11-01" @default.
• W247177564 modified "2023-10-16" @default.
• W247177564 title "The Influence of Acute Overdistension on Rat Bladder Function and DNA Synthesis" @default.
• W247177564 cites W1906197854 @default.
• W247177564 cites W1972352580 @default.
• W247177564 cites W1973240654 @default.
• W247177564 cites W1995110348 @default.
• W247177564 cites W1997344372 @default.
• W247177564 cites W1999172108 @default.
• W247177564 cites W2001074188 @default.
• W247177564 cites W2003586303 @default.
• W247177564 cites W2008529550 @default.
• W247177564 cites W2018070655 @default.
• W247177564 cites W2026288049 @default.
• W247177564 cites W2039773733 @default.
• W247177564 cites W2040112873 @default.
• W247177564 cites W2044098290 @default.
• W247177564 cites W2044717712 @default.
• W247177564 cites W2052472068 @default.
• W247177564 cites W2072593023 @default.
• W247177564 cites W2080567359 @default.
• W247177564 cites W2098973758 @default.
• W247177564 cites W2120063424 @default.
• W247177564 cites W2399178727 @default.
• W247177564 cites W2413766694 @default.
• W247177564 cites W2414042159 @default.
• W247177564 cites W2437120877 @default.
• W247177564 cites W2468007041 @default.
• W247177564 doi "https://doi.org/10.1016/s0022-5347(17)35836-6" @default.
• W247177564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8411448" @default.
• W247177564 hasPublicationYear "1993" @default.
• W247177564 type Work @default.
• W247177564 sameAs 247177564 @default.
• W247177564 citedByCount "36" @default.
• W247177564 countsByYear W2471775642012 @default.
• W247177564 countsByYear W2471775642014 @default.
• W247177564 countsByYear W2471775642016 @default.
• W247177564 countsByYear W2471775642021 @default.
• W247177564 crossrefType "journal-article" @default.
• W247177564 hasAuthorship W247177564A5011425417 @default.
• W247177564 hasAuthorship W247177564A5034890219 @default.
• W247177564 hasAuthorship W247177564A5042687042 @default.
• W247177564 hasAuthorship W247177564A5055176143 @default.
• W247177564 hasAuthorship W247177564A5086843638 @default.
• W247177564 hasConcept C126322002 @default.
• W247177564 hasConcept C126894567 @default.
• W247177564 hasConcept C175768497 @default.
• W247177564 hasConcept C2779091618 @default.
• W247177564 hasConcept C2779762690 @default.
• W247177564 hasConcept C71924100 @default.
• W247177564 hasConcept C77411442 @default.
• W247177564 hasConceptScore W247177564C126322002 @default.
• W247177564 hasConceptScore W247177564C126894567 @default.
• W247177564 hasConceptScore W247177564C175768497 @default.
• W247177564 hasConceptScore W247177564C2779091618 @default.
• W247177564 hasConceptScore W247177564C2779762690 @default.
• W247177564 hasConceptScore W247177564C71924100 @default.
• W247177564 hasConceptScore W247177564C77411442 @default.
• W247177564 hasIssue "5 Part 1" @default.
• W247177564 hasLocation W2471775641 @default.
• W247177564 hasLocation W2471775642 @default.
• W247177564 hasOpenAccess W247177564 @default.
• W247177564 hasPrimaryLocation W2471775641 @default.
• W247177564 hasRelatedWork W2003586303 @default.
• W247177564 hasRelatedWork W2007222984 @default.
• W247177564 hasRelatedWork W2052862931 @default.
• W247177564 hasRelatedWork W2146226077 @default.
• W247177564 hasRelatedWork W2151543183 @default.
• W247177564 hasRelatedWork W2181533209 @default.
• W247177564 hasRelatedWork W2323333738 @default.
• W247177564 hasRelatedWork W2369238124 @default.
• W247177564 hasRelatedWork W2381274486 @default.
• W247177564 hasRelatedWork W2398156664 @default.
• W247177564 hasVolume "150" @default.
• W247177564 isParatext "false" @default.
• W247177564 isRetracted "false" @default.
• W247177564 magId "247177564" @default.
• W247177564 workType "article" @default.