Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471906663> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2471906663 endingPage "41" @default.
- W2471906663 startingPage "1636" @default.
- W2471906663 abstract "This study aims to investigate the contribution of presynaptic nicotinic acetylcholine receptors (nAChRs) sub-types to nicotine-induced enhancement in electrical field stimulation (EFS) EFS-mediated contractile responses in rabbit urine bladder smooth muscle preparations.Rabbit urine bladder smooth muscle strips were placed in organ baths containing 20 ml of an aerated Krebs-Henseleit solution, and contractions were recorded using isometric force displacement transducers. Following the acquisition of control EFS (60 V, 8 Hz, 1 ms) responses, nicotine was added to the bath at a 3×10-5 M concentration, and EFS responses were obtained. The effect of nAChR antagonists on nicotine-induced augmentation in EFS-mediated responses was investigated in the presence of hexamethonium, dihydro-β-erythroidine, mecamylamine, and α-bungarotoxin.Tetrodotoxin (TTX; 10-6 M) completely blocked EFS-induced contractile responses in smooth muscle strips. Similarly, Atropine (10-6 M), when administered with α,β-methylene adenosine triphosphate (α,β-methylene-ATP) (10-5 M), completely blocked EFS responses. Nicotine significantly enhanced EFS-mediated contractile responses (23.67% ± 1.75). Nicotine-induced increases in EFS responses were largely inhibited by hexamethonium, mecamylamine, and dihydro-β-erythroidine, whereas α-bungarotoxin only partly inhibited these enhancements.These findings demonstrate that EFS-induced neurogenic contractions in rabbit urine bladder smooth muscle strips are mediated by purinergic and cholinergic transmissions, and the α4β2, α3β4, and α7 sub-types of nAChRs contribute to the enhancement effect of nicotine on EFS-induced contractile responses." @default.
- W2471906663 created "2016-07-22" @default.
- W2471906663 creator A5039865520 @default.
- W2471906663 creator A5044645148 @default.
- W2471906663 creator A5045557454 @default.
- W2471906663 creator A5059623280 @default.
- W2471906663 creator A5079331072 @default.
- W2471906663 creator A5090529804 @default.
- W2471906663 creator A5087724700 @default.
- W2471906663 date "2016-04-01" @default.
- W2471906663 modified "2023-10-16" @default.
- W2471906663 title "Role of nicotinic acetylcholine receptor subtypes on nicotine's enhancing effect on electrical field stimulation elicited contractile responses in rabbit urine bladder." @default.
- W2471906663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27160140" @default.
- W2471906663 hasPublicationYear "2016" @default.
- W2471906663 type Work @default.
- W2471906663 sameAs 2471906663 @default.
- W2471906663 citedByCount "1" @default.
- W2471906663 countsByYear W24719066632022 @default.
- W2471906663 crossrefType "journal-article" @default.
- W2471906663 hasAuthorship W2471906663A5039865520 @default.
- W2471906663 hasAuthorship W2471906663A5044645148 @default.
- W2471906663 hasAuthorship W2471906663A5045557454 @default.
- W2471906663 hasAuthorship W2471906663A5059623280 @default.
- W2471906663 hasAuthorship W2471906663A5079331072 @default.
- W2471906663 hasAuthorship W2471906663A5087724700 @default.
- W2471906663 hasAuthorship W2471906663A5090529804 @default.
- W2471906663 hasConcept C126322002 @default.
- W2471906663 hasConcept C134018914 @default.
- W2471906663 hasConcept C170493617 @default.
- W2471906663 hasConcept C185592680 @default.
- W2471906663 hasConcept C188987157 @default.
- W2471906663 hasConcept C22885893 @default.
- W2471906663 hasConcept C24998067 @default.
- W2471906663 hasConcept C2775893369 @default.
- W2471906663 hasConcept C2775910092 @default.
- W2471906663 hasConcept C2776880047 @default.
- W2471906663 hasConcept C2776885963 @default.
- W2471906663 hasConcept C2777952989 @default.
- W2471906663 hasConcept C2779547902 @default.
- W2471906663 hasConcept C2779570518 @default.
- W2471906663 hasConcept C2780374058 @default.
- W2471906663 hasConcept C2781005078 @default.
- W2471906663 hasConcept C2909754679 @default.
- W2471906663 hasConcept C33789571 @default.
- W2471906663 hasConcept C71924100 @default.
- W2471906663 hasConcept C80161118 @default.
- W2471906663 hasConcept C98274493 @default.
- W2471906663 hasConceptScore W2471906663C126322002 @default.
- W2471906663 hasConceptScore W2471906663C134018914 @default.
- W2471906663 hasConceptScore W2471906663C170493617 @default.
- W2471906663 hasConceptScore W2471906663C185592680 @default.
- W2471906663 hasConceptScore W2471906663C188987157 @default.
- W2471906663 hasConceptScore W2471906663C22885893 @default.
- W2471906663 hasConceptScore W2471906663C24998067 @default.
- W2471906663 hasConceptScore W2471906663C2775893369 @default.
- W2471906663 hasConceptScore W2471906663C2775910092 @default.
- W2471906663 hasConceptScore W2471906663C2776880047 @default.
- W2471906663 hasConceptScore W2471906663C2776885963 @default.
- W2471906663 hasConceptScore W2471906663C2777952989 @default.
- W2471906663 hasConceptScore W2471906663C2779547902 @default.
- W2471906663 hasConceptScore W2471906663C2779570518 @default.
- W2471906663 hasConceptScore W2471906663C2780374058 @default.
- W2471906663 hasConceptScore W2471906663C2781005078 @default.
- W2471906663 hasConceptScore W2471906663C2909754679 @default.
- W2471906663 hasConceptScore W2471906663C33789571 @default.
- W2471906663 hasConceptScore W2471906663C71924100 @default.
- W2471906663 hasConceptScore W2471906663C80161118 @default.
- W2471906663 hasConceptScore W2471906663C98274493 @default.
- W2471906663 hasIssue "8" @default.
- W2471906663 hasLocation W24719066631 @default.
- W2471906663 hasOpenAccess W2471906663 @default.
- W2471906663 hasPrimaryLocation W24719066631 @default.
- W2471906663 hasRelatedWork W175687658 @default.
- W2471906663 hasRelatedWork W1914383463 @default.
- W2471906663 hasRelatedWork W1972889490 @default.
- W2471906663 hasRelatedWork W1993057350 @default.
- W2471906663 hasRelatedWork W2044186126 @default.
- W2471906663 hasRelatedWork W2061789680 @default.
- W2471906663 hasRelatedWork W2094292011 @default.
- W2471906663 hasRelatedWork W2166834730 @default.
- W2471906663 hasRelatedWork W2471906663 @default.
- W2471906663 hasRelatedWork W2147422825 @default.
- W2471906663 hasVolume "20" @default.
- W2471906663 isParatext "false" @default.
- W2471906663 isRetracted "false" @default.
- W2471906663 magId "2471906663" @default.
- W2471906663 workType "article" @default.