FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2472019910> ?p ?o ?g. }

• W2472019910 endingPage "481" @default.
• W2472019910 startingPage "471" @default.
• W2472019910 abstract "The epidermal growth factor receptor (EGFR) is a clinically validated target in head and neck squamous cell carcinoma (HNSCC), where EGFR-blocking antibodies are approved for first-line treatment. However, as with other targeted therapies, intrinsic/acquired resistance mechanisms limit efficacy. In the FaDu HNSCC xenograft model, we show that combined blockade of EGFR and ERBB3 promotes rapid tumor regression, followed by the eventual outgrowth of resistant cells. RNA sequencing revealed that resistant cells express FGFR3-TACC3 fusion proteins, which were validated as drivers of the resistant phenotype by several approaches, including CRISPR-mediated inactivation of FGFR3-TACC3 fusion genes. Interestingly, analysis of signaling in resistant cell lines demonstrated that FGFR3-TACC3 fusion proteins promote resistance by preferentially substituting for EGFR/RAS/ERK signaling rather than ERBB3/PI3K/AKT signaling. Furthermore, although FGFR3-TACC3 fusion proteins promote resistance of additional EGFR-dependent HNSCC and lung cancer cell lines to EGFR blockade, they are unable to compensate for inhibition of PI3K signaling in PIK3CA-mutant HNSCC cell lines. Validation of FGFR3-TACC3 fusion proteins as endogenous drivers of resistance in our screen provides strong evidence that these fusions are capable of substituting for EGFR signaling. Thus, FGFR3-TACC3 fusion proteins may represent a novel mechanism of acquired resistance in EGFR-dependent cancers of multiple cell lineages." @default.
• W2472019910 created "2016-07-22" @default.
• W2472019910 creator A5006969344 @default.
• W2472019910 creator A5015053419 @default.
• W2472019910 creator A5019818762 @default.
• W2472019910 creator A5029586728 @default.
• W2472019910 creator A5053806816 @default.
• W2472019910 creator A5055898350 @default.
• W2472019910 creator A5057533296 @default.
• W2472019910 creator A5067057749 @default.
• W2472019910 creator A5078906917 @default.
• W2472019910 creator A5084150047 @default.
• W2472019910 date "2016-06-27" @default.
• W2472019910 modified "2023-09-27" @default.
• W2472019910 title "FGFR3-TACC3 fusion proteins act as naturally occurring drivers of tumor resistance by functionally substituting for EGFR/ERK signaling" @default.
• W2472019910 cites W1960850967 @default.
• W2472019910 cites W1966455897 @default.
• W2472019910 cites W1967279935 @default.
• W2472019910 cites W1967394241 @default.
• W2472019910 cites W1969391810 @default.
• W2472019910 cites W1972947623 @default.
• W2472019910 cites W1973260880 @default.
• W2472019910 cites W1979056373 @default.
• W2472019910 cites W1985585626 @default.
• W2472019910 cites W1986241711 @default.
• W2472019910 cites W1994075309 @default.
• W2472019910 cites W2002714006 @default.
• W2472019910 cites W2004893350 @default.
• W2472019910 cites W2005036868 @default.
• W2472019910 cites W2007223616 @default.
• W2472019910 cites W2008550171 @default.
• W2472019910 cites W2020047273 @default.
• W2472019910 cites W2024896457 @default.
• W2472019910 cites W2037690883 @default.
• W2472019910 cites W2039705224 @default.
• W2472019910 cites W2042103473 @default.
• W2472019910 cites W2052705131 @default.
• W2472019910 cites W2053343049 @default.
• W2472019910 cites W2069526613 @default.
• W2472019910 cites W2081069777 @default.
• W2472019910 cites W2085690948 @default.
• W2472019910 cites W2096362504 @default.
• W2472019910 cites W2096869304 @default.
• W2472019910 cites W2101106357 @default.
• W2472019910 cites W2107977954 @default.
• W2472019910 cites W2108246579 @default.
• W2472019910 cites W2110933411 @default.
• W2472019910 cites W2113235293 @default.
• W2472019910 cites W2114200265 @default.
• W2472019910 cites W2119746400 @default.
• W2472019910 cites W2127990562 @default.
• W2472019910 cites W2132394486 @default.
• W2472019910 cites W2142564546 @default.
• W2472019910 cites W2154469201 @default.
• W2472019910 cites W2155384808 @default.
• W2472019910 cites W2158819778 @default.
• W2472019910 cites W2159639650 @default.
• W2472019910 cites W2160574552 @default.
• W2472019910 cites W2161821474 @default.
• W2472019910 cites W2165267819 @default.
• W2472019910 cites W2263837770 @default.
• W2472019910 cites W2409420104 @default.
• W2472019910 doi "https://doi.org/10.1038/onc.2016.216" @default.
• W2472019910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5290037" @default.
• W2472019910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27345413" @default.
• W2472019910 hasPublicationYear "2016" @default.
• W2472019910 type Work @default.
• W2472019910 sameAs 2472019910 @default.
• W2472019910 citedByCount "39" @default.
• W2472019910 countsByYear W24720199102016 @default.
• W2472019910 countsByYear W24720199102017 @default.
• W2472019910 countsByYear W24720199102018 @default.
• W2472019910 countsByYear W24720199102019 @default.
• W2472019910 countsByYear W24720199102020 @default.
• W2472019910 countsByYear W24720199102021 @default.
• W2472019910 countsByYear W24720199102022 @default.
• W2472019910 countsByYear W24720199102023 @default.
• W2472019910 crossrefType "journal-article" @default.
• W2472019910 hasAuthorship W2472019910A5006969344 @default.
• W2472019910 hasAuthorship W2472019910A5015053419 @default.
• W2472019910 hasAuthorship W2472019910A5019818762 @default.
• W2472019910 hasAuthorship W2472019910A5029586728 @default.
• W2472019910 hasAuthorship W2472019910A5053806816 @default.
• W2472019910 hasAuthorship W2472019910A5055898350 @default.
• W2472019910 hasAuthorship W2472019910A5057533296 @default.
• W2472019910 hasAuthorship W2472019910A5067057749 @default.
• W2472019910 hasAuthorship W2472019910A5078906917 @default.
• W2472019910 hasAuthorship W2472019910A5084150047 @default.
• W2472019910 hasBestOaLocation W24720199101 @default.
• W2472019910 hasConcept C104317684 @default.
• W2472019910 hasConcept C115456853 @default.
• W2472019910 hasConcept C116227048 @default.
• W2472019910 hasConcept C121608353 @default.
• W2472019910 hasConcept C123894998 @default.
• W2472019910 hasConcept C161879069 @default.
• W2472019910 hasConcept C2777506169 @default.
• W2472019910 hasConcept C2779438470 @default.
• W2472019910 hasConcept C40767141 @default.

• next