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- W2472022668 endingPage "730" @default.
- W2472022668 startingPage "712" @default.
- W2472022668 abstract "During evolution, cells acquired the ability to sense and adapt to varying environmental conditions, particularly in terms of fuel supply. Adaptation to fuel availability is crucial for major cell decisions and requires metabolic alterations and differential gene expression that are often epigenetically driven. A new mechanistic link between metabolic flux and regulation of gene expression is through moonlighting of metabolic enzymes in the nucleus. This facilitates delivery of membrane-impermeable or unstable metabolites to the nucleus, including key substrates for epigenetic mechanisms such as acetyl-CoA which is used in histone acetylation. This metabolism-epigenetics axis facilitates adaptation to a changing environment in normal (e.g., development, stem cell differentiation) and disease states (e.g., cancer), providing a potential novel therapeutic target." @default.
- W2472022668 created "2016-07-22" @default.
- W2472022668 creator A5004686625 @default.
- W2472022668 creator A5021152638 @default.
- W2472022668 creator A5082870009 @default.
- W2472022668 date "2016-08-01" @default.
- W2472022668 modified "2023-10-05" @default.
- W2472022668 title "Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription" @default.
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