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• W2472023498 abstract "Abstract MicroRNAs (miRNAs) have been reported to be involved in DNA damage response induced by ionizing radiation (IR). c-Myc is reduced when cells treated with IR or other DNA damaging agents. It is unknown whether miRNAs participate in c-Myc downregulation in response to IR. In the present study, we found that miR-449a enhanced radiosensitivity in vitro and in vivo by targeting c-Myc in prostate cancer (LNCaP) cells. MiR-449a was upregulated and c-Myc was downregulated in response to IR in LNCaP cells. Overexpression of miR-449a or knockdown of c-Myc promoted the sensitivity of LNCaP cells to IR. By establishing c-Myc as a direct target of miR-449a, we revealed that miR-449a enhanced radiosensitivity by repressing c-Myc expression in LNCaP cells. Furthermore, we showed that miR-449a enhanced radiation-induced G2/M phase arrest by directly downregulating c-Myc, which controlled the Cdc2/CyclinB1 cell cycle signal by modulating Cdc25A. These results highlight an unrecognized mechanism of miR-449a-mediated c-Myc regulation in response to IR and may provide alternative therapeutic strategies for the treatment of prostate cancer." @default.
• W2472023498 created "2016-07-22" @default.
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• W2472023498 date "2016-06-02" @default.
• W2472023498 modified "2023-10-03" @default.
• W2472023498 title "MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells" @default.
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• W2472023498 doi "https://doi.org/10.1038/srep27346" @default.
• W2472023498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4890029" @default.
• W2472023498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27250340" @default.
• W2472023498 hasPublicationYear "2016" @default.
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