Matches in SemOpenAlex for { <https://semopenalex.org/work/W2472065315> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2472065315 abstract "Neuropathic pain is a serious clinical problem and difficult to treat. Nerve injury causes a long-lasting reduction in potassium channel expression in the dorsal root ganglion (DRG), but little is known about the epigenetic mechanisms involved. Using a rat model of neuropathic pain, we found that nerve injury significantly increased the expression and activity of G9a, histone deacetylases (HDACs), and EZH2 in the DRG. Chromatin immunoprecipitation analysis revealed that nerve injury consistently increased H3K9me2 occupancy at Kcna4, Kcnd2, Kcnq2 and Kcnma1 promoters. However, nerve injury had no effect on the DNA methylation levels of these potassium channel genes in the DRG. Only G9a inhibition consistently restored potassium channel expression and potassium channel activity of DRG neurons. In addition, intrathecal treatment with G9a-specific siRNA or selective G9a knockout in DRG neurons prevented potassium channel silencing and chronic pain development after nerve injury. Thus G9a plays a dominant role in transcriptional repression of potassium channels in primary sensory neurons and in the transition from acute to chronic pain after nerve injury." @default.
- W2472065315 created "2016-07-22" @default.
- W2472065315 creator A5020048782 @default.
- W2472065315 creator A5025851353 @default.
- W2472065315 creator A5075417991 @default.
- W2472065315 creator A5080420947 @default.
- W2472065315 date "2016-02-01" @default.
- W2472065315 modified "2023-09-29" @default.
- W2472065315 title "Transcriptional Regulation of Potassium Channel Expression by G9a in Neuropathic Pain" @default.
- W2472065315 doi "https://doi.org/10.1016/j.bpj.2015.11.3237" @default.
- W2472065315 hasPublicationYear "2016" @default.
- W2472065315 type Work @default.
- W2472065315 sameAs 2472065315 @default.
- W2472065315 citedByCount "0" @default.
- W2472065315 crossrefType "journal-article" @default.
- W2472065315 hasAuthorship W2472065315A5020048782 @default.
- W2472065315 hasAuthorship W2472065315A5025851353 @default.
- W2472065315 hasAuthorship W2472065315A5075417991 @default.
- W2472065315 hasAuthorship W2472065315A5080420947 @default.
- W2472065315 hasBestOaLocation W24720653151 @default.
- W2472065315 hasConcept C101762097 @default.
- W2472065315 hasConcept C104317684 @default.
- W2472065315 hasConcept C119056186 @default.
- W2472065315 hasConcept C126322002 @default.
- W2472065315 hasConcept C134320426 @default.
- W2472065315 hasConcept C150194340 @default.
- W2472065315 hasConcept C169760540 @default.
- W2472065315 hasConcept C185592680 @default.
- W2472065315 hasConcept C2775991916 @default.
- W2472065315 hasConcept C2776281502 @default.
- W2472065315 hasConcept C2776880756 @default.
- W2472065315 hasConcept C2777107010 @default.
- W2472065315 hasConcept C2781118164 @default.
- W2472065315 hasConcept C2781149210 @default.
- W2472065315 hasConcept C41091548 @default.
- W2472065315 hasConcept C42219234 @default.
- W2472065315 hasConcept C55493867 @default.
- W2472065315 hasConcept C64927066 @default.
- W2472065315 hasConcept C71924100 @default.
- W2472065315 hasConcept C83743174 @default.
- W2472065315 hasConcept C86803240 @default.
- W2472065315 hasConcept C94487597 @default.
- W2472065315 hasConcept C95444343 @default.
- W2472065315 hasConcept C98274493 @default.
- W2472065315 hasConceptScore W2472065315C101762097 @default.
- W2472065315 hasConceptScore W2472065315C104317684 @default.
- W2472065315 hasConceptScore W2472065315C119056186 @default.
- W2472065315 hasConceptScore W2472065315C126322002 @default.
- W2472065315 hasConceptScore W2472065315C134320426 @default.
- W2472065315 hasConceptScore W2472065315C150194340 @default.
- W2472065315 hasConceptScore W2472065315C169760540 @default.
- W2472065315 hasConceptScore W2472065315C185592680 @default.
- W2472065315 hasConceptScore W2472065315C2775991916 @default.
- W2472065315 hasConceptScore W2472065315C2776281502 @default.
- W2472065315 hasConceptScore W2472065315C2776880756 @default.
- W2472065315 hasConceptScore W2472065315C2777107010 @default.
- W2472065315 hasConceptScore W2472065315C2781118164 @default.
- W2472065315 hasConceptScore W2472065315C2781149210 @default.
- W2472065315 hasConceptScore W2472065315C41091548 @default.
- W2472065315 hasConceptScore W2472065315C42219234 @default.
- W2472065315 hasConceptScore W2472065315C55493867 @default.
- W2472065315 hasConceptScore W2472065315C64927066 @default.
- W2472065315 hasConceptScore W2472065315C71924100 @default.
- W2472065315 hasConceptScore W2472065315C83743174 @default.
- W2472065315 hasConceptScore W2472065315C86803240 @default.
- W2472065315 hasConceptScore W2472065315C94487597 @default.
- W2472065315 hasConceptScore W2472065315C95444343 @default.
- W2472065315 hasConceptScore W2472065315C98274493 @default.
- W2472065315 hasLocation W24720653151 @default.
- W2472065315 hasOpenAccess W2472065315 @default.
- W2472065315 hasPrimaryLocation W24720653151 @default.
- W2472065315 hasRelatedWork W1551383644 @default.
- W2472065315 hasRelatedWork W1969076414 @default.
- W2472065315 hasRelatedWork W2046979252 @default.
- W2472065315 hasRelatedWork W2076160249 @default.
- W2472065315 hasRelatedWork W2093547160 @default.
- W2472065315 hasRelatedWork W2283502293 @default.
- W2472065315 hasRelatedWork W2535842047 @default.
- W2472065315 hasRelatedWork W2549105334 @default.
- W2472065315 hasRelatedWork W2734426860 @default.
- W2472065315 hasRelatedWork W2767349340 @default.
- W2472065315 hasRelatedWork W2794643834 @default.
- W2472065315 hasRelatedWork W2893032714 @default.
- W2472065315 hasRelatedWork W2897089280 @default.
- W2472065315 hasRelatedWork W2902736748 @default.
- W2472065315 hasRelatedWork W2914934100 @default.
- W2472065315 hasRelatedWork W2921379023 @default.
- W2472065315 hasRelatedWork W2951435427 @default.
- W2472065315 hasRelatedWork W3005494370 @default.
- W2472065315 hasRelatedWork W3031377513 @default.
- W2472065315 hasRelatedWork W3158525996 @default.
- W2472065315 isParatext "false" @default.
- W2472065315 isRetracted "false" @default.
- W2472065315 magId "2472065315" @default.
- W2472065315 workType "article" @default.