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- W2472163898 abstract "AbstractFluoroquinolone antibacterials rapidly kill susceptible bacteria at clinically relevant drug concentrations; all evidence indicates that these drugs exert their lethality on Escherichia coli by inhibiting the normal function of the DNA gyrase (a bacterial topoisomerase II) in this organism. Mutations around a limited region of the DNA gyrase A subunit (residues Ala67-Gln106) have been shown to confer resistance to these agents in E. coli (1). This has also been documented in many other organisms, indicating that DNA gyrase is a universal target for these drugs. This relationship has been somewhat complicated recently by the observation that in Staphylococcus aureus, mutations in another type II enzyme, topoisomerase IV, also confer resistance to fluoroquinolones (2).KeywordsMinimal Inhibitory ConcentrationBactericidal TestCleavable ComplexMinimal Inhibitory Concentration RangeMinimal Inhibitory Concentration TestThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W2472163898 created "2016-07-22" @default.
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- W2472163898 date "2003-11-14" @default.
- W2472163898 modified "2023-09-26" @default.
- W2472163898 title "Bactericidal Assays for Fluoroquinolones" @default.
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- W2472163898 doi "https://doi.org/10.1385/1-59259-057-8:185" @default.
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