Matches in SemOpenAlex for { <https://semopenalex.org/work/W2472173303> ?p ?o ?g. }
- W2472173303 endingPage "349" @default.
- W2472173303 startingPage "332" @default.
- W2472173303 abstract "Studies have reported that interactions between keratins (KRTs) and other proteins initiate signaling cascades that regulate cell migration, invasion, and metastasis. In the current study, we found that expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Moreover, knockdown of KRT19 led to increased proliferation, migration, invasion, drug resistance, and sphere formation in breast cancer cells via an upregulated NOTCH signaling pathway. This was owing to reduced expression of NUMB, an inhibitory protein of the NOTCH signaling pathway. In addition, we found that KRT19 interacts with β-catenin/RAC1 complex and enhances the nuclear translocation of β-catenin. Concordantly, knockdown of KRT19 suppressed the nuclear translocation of β-catenin as well as β-catenin-mediated NUMB expression. Furthermore, modulation of KRT19-mediated regulation of NUMB and NOTCH1 expression led to the repression of the cancer stem cell properties of breast cancer patient-derived CD133high/CXCR4high/ALDH1high cancer stem-like cells (CSLCs), which showed very low KRT19 and high NOTCH1 expression. Taken together, our study suggests a novel function for KRT19 in the regulation of nuclear import of the β-catenin/RAC1 complex, thus modulating the NUMB-dependent NOTCH signaling pathway in breast cancers and CSLCs, which might bear potential clinical implications for cancer or CSLC treatment." @default.
- W2472173303 created "2016-07-22" @default.
- W2472173303 creator A5003992894 @default.
- W2472173303 creator A5036870343 @default.
- W2472173303 creator A5040115179 @default.
- W2472173303 creator A5063095740 @default.
- W2472173303 creator A5067277192 @default.
- W2472173303 creator A5069563388 @default.
- W2472173303 creator A5078699272 @default.
- W2472173303 creator A5082891935 @default.
- W2472173303 date "2016-06-27" @default.
- W2472173303 modified "2023-10-17" @default.
- W2472173303 title "KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties" @default.
- W2472173303 cites W1965416841 @default.
- W2472173303 cites W1968428572 @default.
- W2472173303 cites W1970265615 @default.
- W2472173303 cites W1974096298 @default.
- W2472173303 cites W1974679405 @default.
- W2472173303 cites W1976302659 @default.
- W2472173303 cites W1977342829 @default.
- W2472173303 cites W1978116730 @default.
- W2472173303 cites W1978478424 @default.
- W2472173303 cites W1979760591 @default.
- W2472173303 cites W1984609955 @default.
- W2472173303 cites W1994754524 @default.
- W2472173303 cites W1994930469 @default.
- W2472173303 cites W1999027637 @default.
- W2472173303 cites W2001992345 @default.
- W2472173303 cites W2003938487 @default.
- W2472173303 cites W2006514214 @default.
- W2472173303 cites W2010557900 @default.
- W2472173303 cites W2018425992 @default.
- W2472173303 cites W2018868898 @default.
- W2472173303 cites W2020291298 @default.
- W2472173303 cites W2022330566 @default.
- W2472173303 cites W2028094847 @default.
- W2472173303 cites W2031907729 @default.
- W2472173303 cites W2034048622 @default.
- W2472173303 cites W2035231686 @default.
- W2472173303 cites W2035396934 @default.
- W2472173303 cites W2037965946 @default.
- W2472173303 cites W2038164707 @default.
- W2472173303 cites W2041156138 @default.
- W2472173303 cites W2042726246 @default.
- W2472173303 cites W2044082982 @default.
- W2472173303 cites W2046488041 @default.
- W2472173303 cites W2047142430 @default.
- W2472173303 cites W2052152283 @default.
- W2472173303 cites W2052701545 @default.
- W2472173303 cites W2062150443 @default.
- W2472173303 cites W2062755839 @default.
- W2472173303 cites W2066236382 @default.
- W2472173303 cites W2067129601 @default.
- W2472173303 cites W2080810211 @default.
- W2472173303 cites W2081028905 @default.
- W2472173303 cites W2082894007 @default.
- W2472173303 cites W2083205626 @default.
- W2472173303 cites W2087811918 @default.
- W2472173303 cites W2088257765 @default.
- W2472173303 cites W2088539039 @default.
- W2472173303 cites W2092123619 @default.
- W2472173303 cites W2094543320 @default.
- W2472173303 cites W2095904711 @default.
- W2472173303 cites W2100689028 @default.
- W2472173303 cites W2101885447 @default.
- W2472173303 cites W2102645961 @default.
- W2472173303 cites W2102869463 @default.
- W2472173303 cites W2104271563 @default.
- W2472173303 cites W2104593525 @default.
- W2472173303 cites W2108900994 @default.
- W2472173303 cites W2115790079 @default.
- W2472173303 cites W2118413367 @default.
- W2472173303 cites W2119075044 @default.
- W2472173303 cites W2121419223 @default.
- W2472173303 cites W2121429119 @default.
- W2472173303 cites W2121672045 @default.
- W2472173303 cites W2123140856 @default.
- W2472173303 cites W2124475426 @default.
- W2472173303 cites W2124953890 @default.
- W2472173303 cites W2127594372 @default.
- W2472173303 cites W2127743415 @default.
- W2472173303 cites W2131596261 @default.
- W2472173303 cites W2133030708 @default.
- W2472173303 cites W2133503086 @default.
- W2472173303 cites W2136029031 @default.
- W2472173303 cites W2137367185 @default.
- W2472173303 cites W2146949185 @default.
- W2472173303 cites W2147162859 @default.
- W2472173303 cites W2149226292 @default.
- W2472173303 cites W2153454576 @default.
- W2472173303 cites W2154453972 @default.
- W2472173303 cites W2154861644 @default.
- W2472173303 cites W2156273110 @default.
- W2472173303 cites W2156414461 @default.
- W2472173303 cites W2159950734 @default.
- W2472173303 cites W2163179623 @default.
- W2472173303 cites W2163563958 @default.
- W2472173303 cites W2164457542 @default.