Matches in SemOpenAlex for { <https://semopenalex.org/work/W2472365720> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2472365720 endingPage "94" @default.
- W2472365720 startingPage "889" @default.
- W2472365720 abstract "Cyclosporin-A (CsA) is a potent immunoregulatory molecule which has been widely used in many immunomediated and inflammatory skin diseases. It inhibits the proliferation of keratinocytes, but its possible effects(s) on cell differentiation are poorly known. To address this issue, we have studied the influence of CsA on the assembly of intermediate filaments by normal human keratinocytes in culture. Control keratinocytes were flat; the cells which had not reached confluence stained intensely for vimentin and weakly for cytokeratins; confluent cells stained with intermediate intensity for both types of proteins and the cells adhering on the top of others, interpreted as the best differentiated ones, stained for cytokeratins but not for vimentin. CsA (1.6 micrograms/ml for 10 days) inhibited the growth of keratinocytes, which never reached confluence; most cells appeared small and roundish, only some stained for cytokeratins and few for vimentin. By electron microscopy, a well organized meshwork of tonofibrils was recognized in many control keratinocytes, but never in CsA-treated keratinocytes. We propose that the cytoskeleton could be a target of CsA and that its alteration mediates other effects of CsA on keratinocytes, including those on cell growth." @default.
- W2472365720 created "2016-07-22" @default.
- W2472365720 creator A5010943353 @default.
- W2472365720 creator A5027715802 @default.
- W2472365720 creator A5043724231 @default.
- W2472365720 creator A5069653954 @default.
- W2472365720 creator A5082487306 @default.
- W2472365720 date "1996-10-01" @default.
- W2472365720 modified "2023-09-23" @default.
- W2472365720 title "Cyclosporin-A affects the organization of cytoskeleton of normal human keratinocytes in culture." @default.
- W2472365720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8930631" @default.
- W2472365720 hasPublicationYear "1996" @default.
- W2472365720 type Work @default.
- W2472365720 sameAs 2472365720 @default.
- W2472365720 citedByCount "5" @default.
- W2472365720 countsByYear W24723657202016 @default.
- W2472365720 countsByYear W24723657202020 @default.
- W2472365720 crossrefType "journal-article" @default.
- W2472365720 hasAuthorship W2472365720A5010943353 @default.
- W2472365720 hasAuthorship W2472365720A5027715802 @default.
- W2472365720 hasAuthorship W2472365720A5043724231 @default.
- W2472365720 hasAuthorship W2472365720A5069653954 @default.
- W2472365720 hasAuthorship W2472365720A5082487306 @default.
- W2472365720 hasConcept C142669718 @default.
- W2472365720 hasConcept C142724271 @default.
- W2472365720 hasConcept C147447768 @default.
- W2472365720 hasConcept C1491633281 @default.
- W2472365720 hasConcept C185592680 @default.
- W2472365720 hasConcept C203014093 @default.
- W2472365720 hasConcept C204232928 @default.
- W2472365720 hasConcept C2777074287 @default.
- W2472365720 hasConcept C54355233 @default.
- W2472365720 hasConcept C55493867 @default.
- W2472365720 hasConcept C71924100 @default.
- W2472365720 hasConcept C78383274 @default.
- W2472365720 hasConcept C81241287 @default.
- W2472365720 hasConcept C81885089 @default.
- W2472365720 hasConcept C86803240 @default.
- W2472365720 hasConcept C95444343 @default.
- W2472365720 hasConceptScore W2472365720C142669718 @default.
- W2472365720 hasConceptScore W2472365720C142724271 @default.
- W2472365720 hasConceptScore W2472365720C147447768 @default.
- W2472365720 hasConceptScore W2472365720C1491633281 @default.
- W2472365720 hasConceptScore W2472365720C185592680 @default.
- W2472365720 hasConceptScore W2472365720C203014093 @default.
- W2472365720 hasConceptScore W2472365720C204232928 @default.
- W2472365720 hasConceptScore W2472365720C2777074287 @default.
- W2472365720 hasConceptScore W2472365720C54355233 @default.
- W2472365720 hasConceptScore W2472365720C55493867 @default.
- W2472365720 hasConceptScore W2472365720C71924100 @default.
- W2472365720 hasConceptScore W2472365720C78383274 @default.
- W2472365720 hasConceptScore W2472365720C81241287 @default.
- W2472365720 hasConceptScore W2472365720C81885089 @default.
- W2472365720 hasConceptScore W2472365720C86803240 @default.
- W2472365720 hasConceptScore W2472365720C95444343 @default.
- W2472365720 hasIssue "4" @default.
- W2472365720 hasLocation W24723657201 @default.
- W2472365720 hasOpenAccess W2472365720 @default.
- W2472365720 hasPrimaryLocation W24723657201 @default.
- W2472365720 hasRelatedWork W129824029 @default.
- W2472365720 hasRelatedWork W1977586117 @default.
- W2472365720 hasRelatedWork W2038425676 @default.
- W2472365720 hasRelatedWork W2057273083 @default.
- W2472365720 hasRelatedWork W2058997170 @default.
- W2472365720 hasRelatedWork W2062523292 @default.
- W2472365720 hasRelatedWork W2075964258 @default.
- W2472365720 hasRelatedWork W2461416972 @default.
- W2472365720 hasRelatedWork W2904625108 @default.
- W2472365720 hasRelatedWork W1807809750 @default.
- W2472365720 hasVolume "11" @default.
- W2472365720 isParatext "false" @default.
- W2472365720 isRetracted "false" @default.
- W2472365720 magId "2472365720" @default.
- W2472365720 workType "article" @default.