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- W2472447381 abstract "The effect of 7 synthetic derivatives of 3-nitrobenzofurane, 3-nitroindol and nitrovynil hydoquinone on tumor growth in F1(C57Bl CBA) mice with subcutaneously inoculated Erlich’s carcinoma (EC) was studied. It was demonstrated that upon 4 daily subcutaneous injections of 5-hydroxy-6,7-dichlor-3-nitrobenzofurane water suspension with a single dose of 400 μg/kg or 5-hydroxy -2-(2-dimethylaminopropene-1-il)-3-nitrobenzofurane with a single dose of 200 μg/kg the growth of EC was inhibited significantly up to 61 – 67 % with respect to tumor volume, which is supported by significant reduction of tumor weight upon the treatment period up to 24 %. We have observed that the efficacy of treatment was recorded as early as 4 day after the beginning the therapy and remained at the significant level declining to 48 – 49 % after 1 week of treatment. The continuation of therapy failed to retain the achieved effect. All of tested compounds proved well tolerable in case of long-term administration at the dosages applied. The results obtained provide a basis for subsequent studies of these nitro derivatives in other tumor growth models." @default.
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- W2472447381 date "2009-01-01" @default.
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- W2472447381 title "GROWTH DYNAMICS OF ERLICH'S CARCINOMA IN F1 MICE UNDER THE EFFECT OF NO DONORS - 3-NITROBENZOFURANE AND 3-NITROINDOL DERIVATIVES" @default.
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