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- W2472642267 abstract "Although typically mild, transient, and expected, most adverse events (AEs) postsclerotherapy are inflammatory in nature.To evaluate the effects of a high-potency topical corticosteroid (TC) applied immediately postsclerotherapy.Subjects undergoing bilateral lower extremity sclerotherapy with polidocanol had extremities randomized to a single application of betamethasone dipropionate and placebo saline solutions immediately post-treatment in a double-blind manner. Adverse events were assessed for each extremity by subjects at t = 0 (preapplication) and t = 15 (15 minutes postapplication) and by an investigator at t = 0 and t = 15, and at Days 14 and 60. Subjects and investigator evaluated efficacy with a quartile improvement scale.Sixteen female subjects completed the study. Subjects reported no statistically significant differences in AEs between TC and placebo at either t = 0 or t = 15. Investigator scores for erythema and swelling/urtication were not significantly different between groups at the same time points. Although most subjects demonstrated 26% to 75% improvement at Day 60, results were not significantly different between extremities on subject and investigator evaluation.High-potency TC application immediately postsclerotherapy produced no statistically significant differences in subject- and investigator-assessed AEs and clearance rates compared with placebo. Foam sclerotherapy with polidocanol is safe and effective for the treatment of lower extremity reticular veins." @default.
- W2472642267 created "2016-07-22" @default.
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- W2472642267 date "2015-10-01" @default.
- W2472642267 modified "2023-09-27" @default.
- W2472642267 title "A Randomized, Double-Blind, Placebo-Controlled Study of the Effect of a High-Potency Topical Corticosteroid After Sclerotherapy for Reticular and Telangiectatic Veins of the Lower Extremities" @default.
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- W2472642267 doi "https://doi.org/10.1097/dss.0000000000000467" @default.
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