Matches in SemOpenAlex for { <https://semopenalex.org/work/W2472677086> ?p ?o ?g. }
- W2472677086 endingPage "736" @default.
- W2472677086 startingPage "727" @default.
- W2472677086 abstract "Curcuminoids are high-potential drugs targeting multiple components of vital signaling pathways without being toxic, and are therefore considered to be valuable lead structures in medicinal chemistry. Unfortunately, most curcuminoids poorly reach their site of action because of low bioavailability issues, (partly) associated with the labile β-diketo structure. In that respect, curcumin derivatives bearing a central β-enaminone fragment may have improved solubility and intestinal stability, and therefore may represent a new class of analogs with higher bioactivity. In that mindset, thirteen N-alkyl enaminones were efficiently synthesized via a novel approach, using montmorillonite K10 clay and microwave irradiation. These compounds were then characterized in terms of solubility and chemical anti-oxidant properties, and were applied in screening assays for cell toxicity, growth and oxidative stress using CHO-K1, EA.hy926, HT-29 and Caco-2 cell lines. Compared to native curcumin, many nitrogen derivatives showed a stronger antiproliferative effect, which was highly structure and cell type dependent. In addition, the correlation between cell viability and reactive oxygen species production was limited. Therefore, this set of novel curcumin derivatives may be useful to unravel other mechanisms of oxidative stress-related diseases, and eventually be used as more bioavailable and bioactive alternatives for native curcumin." @default.
- W2472677086 created "2016-07-22" @default.
- W2472677086 creator A5008414429 @default.
- W2472677086 creator A5010607220 @default.
- W2472677086 creator A5012063264 @default.
- W2472677086 creator A5018381676 @default.
- W2472677086 creator A5037957827 @default.
- W2472677086 creator A5049860476 @default.
- W2472677086 creator A5060646429 @default.
- W2472677086 creator A5073712882 @default.
- W2472677086 date "2016-11-01" @default.
- W2472677086 modified "2023-10-01" @default.
- W2472677086 title "Synthesis of novel curcuminoids accommodating a central β-enaminone motif and their impact on cell growth and oxidative stress" @default.
- W2472677086 cites W1550146738 @default.
- W2472677086 cites W1588145958 @default.
- W2472677086 cites W1604068141 @default.
- W2472677086 cites W1942892574 @default.
- W2472677086 cites W1944972564 @default.
- W2472677086 cites W1966295662 @default.
- W2472677086 cites W1974234362 @default.
- W2472677086 cites W1975770667 @default.
- W2472677086 cites W1976194786 @default.
- W2472677086 cites W1976614848 @default.
- W2472677086 cites W1977178308 @default.
- W2472677086 cites W1980229658 @default.
- W2472677086 cites W1985000437 @default.
- W2472677086 cites W1995043836 @default.
- W2472677086 cites W1997684038 @default.
- W2472677086 cites W1998365584 @default.
- W2472677086 cites W2003392863 @default.
- W2472677086 cites W2008107953 @default.
- W2472677086 cites W2019883194 @default.
- W2472677086 cites W2021018857 @default.
- W2472677086 cites W2036382230 @default.
- W2472677086 cites W2041629090 @default.
- W2472677086 cites W2043509228 @default.
- W2472677086 cites W2045533834 @default.
- W2472677086 cites W2049032809 @default.
- W2472677086 cites W2050067055 @default.
- W2472677086 cites W2050634511 @default.
- W2472677086 cites W2057345554 @default.
- W2472677086 cites W2059503903 @default.
- W2472677086 cites W2059978286 @default.
- W2472677086 cites W2071395559 @default.
- W2472677086 cites W2072175441 @default.
- W2472677086 cites W2074682587 @default.
- W2472677086 cites W2075214895 @default.
- W2472677086 cites W2077166822 @default.
- W2472677086 cites W2078068365 @default.
- W2472677086 cites W2079178816 @default.
- W2472677086 cites W2082421277 @default.
- W2472677086 cites W2088681531 @default.
- W2472677086 cites W20888715 @default.
- W2472677086 cites W2098928754 @default.
- W2472677086 cites W2100036263 @default.
- W2472677086 cites W2108015495 @default.
- W2472677086 cites W2109408781 @default.
- W2472677086 cites W2113808782 @default.
- W2472677086 cites W2114467922 @default.
- W2472677086 cites W2117095275 @default.
- W2472677086 cites W2117116660 @default.
- W2472677086 cites W2120203281 @default.
- W2472677086 cites W2121288523 @default.
- W2472677086 cites W2123021412 @default.
- W2472677086 cites W2132886980 @default.
- W2472677086 cites W2134507567 @default.
- W2472677086 cites W2137631271 @default.
- W2472677086 cites W2142687511 @default.
- W2472677086 cites W2153288200 @default.
- W2472677086 cites W2160163010 @default.
- W2472677086 cites W2161229173 @default.
- W2472677086 cites W2165292984 @default.
- W2472677086 cites W2165590213 @default.
- W2472677086 cites W2323547402 @default.
- W2472677086 cites W2417181118 @default.
- W2472677086 cites W2526556170 @default.
- W2472677086 cites W2951488017 @default.
- W2472677086 cites W2951769102 @default.
- W2472677086 doi "https://doi.org/10.1016/j.ejmech.2016.07.017" @default.
- W2472677086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27521589" @default.
- W2472677086 hasPublicationYear "2016" @default.
- W2472677086 type Work @default.
- W2472677086 sameAs 2472677086 @default.
- W2472677086 citedByCount "22" @default.
- W2472677086 countsByYear W24726770862016 @default.
- W2472677086 countsByYear W24726770862017 @default.
- W2472677086 countsByYear W24726770862018 @default.
- W2472677086 countsByYear W24726770862019 @default.
- W2472677086 countsByYear W24726770862020 @default.
- W2472677086 countsByYear W24726770862023 @default.
- W2472677086 crossrefType "journal-article" @default.
- W2472677086 hasAuthorship W2472677086A5008414429 @default.
- W2472677086 hasAuthorship W2472677086A5010607220 @default.
- W2472677086 hasAuthorship W2472677086A5012063264 @default.
- W2472677086 hasAuthorship W2472677086A5018381676 @default.
- W2472677086 hasAuthorship W2472677086A5037957827 @default.
- W2472677086 hasAuthorship W2472677086A5049860476 @default.
- W2472677086 hasAuthorship W2472677086A5060646429 @default.