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- W2472743909 abstract "ABSTRACT. Objective. It is believed that end-stagerenal disease (ESRD) attributable to reflux nephropathyis preventable by the active treatment of vesicouretericreflux in childhood with long-term antibiotics and ure-teric reimplantation surgery. We aimed to test this belief. Methodology. The Australia and New Zealand Dial-ysis and Transplant Registry of new patients 5 to 44 yearsof age treated for ESRD between 1971 and 1998, catego-rized by age and primary renal disease, was used toanalyze the age-specific incidences of ESRD attributableto reflux nephropathy using a before–after study design.The early 1960s were regarded as the introduction periodfor the active treatment of childhood vesicoureteric re-flux. A time-delay in treatment effect was expected. Pa-tients with ESRD attributable to other causes were usedas a comparative group. Results. The incidence of ESRD attributable to refluxnephropathy and nonreflux nephropathy has increased.For reflux nephropathy, the rate of change was signifi-cantly associated with age, with a downward trend inincidence with decreasing age suggesting a minor treat-ment effect. This trend was no longer evident whenadjustment was made for changing diagnostic practices.An opposite trend was observed for the nonreflux ne-phropathy group, who demonstrated an upward trend inincidence with decreasing age." @default.
- W2472743909 created "2016-07-22" @default.
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- W2472743909 date "2014-01-01" @default.
- W2472743909 modified "2023-10-12" @default.
- W2472743909 title "Disease Attributable to Reflux Nephropathy? Does Treatment of Vesicoureteric Reflux in Childhood Prevent End-Stage Renal" @default.
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