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• W2472783235 abstract "Down syndrome (DS) patients invariablydevelop Alzheimer’s disease (AD) pathol-ogy in their 40s. It has been reported thatSNX27deficiencycontributestoimpairedlearning and memory in DS. In this study,Wang et al. show that SNX27 regulatesAPPcleavageandAbgeneration.Inaddi-tion,theysuggestthatSNX27actsasag-secretase interaction partner and showthattheinteractiondissociatestheg-sec-retase complex, thus decreasing its pro-teolytic activity. The results provide anew clue to the pathogenesis of DS andAD." @default.
• W2472783235 created "2016-07-22" @default.
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• W2472783235 date "2014-01-01" @default.
• W2472783235 modified "2023-09-27" @default.
• W2472783235 title "Sorting Nexin 27 Regulates Ab Production through Modulating g-Secretase Activity" @default.
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• W2472783235 hasPublicationYear "2014" @default.
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