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• W2472911856 endingPage "10.1212/WNL.0000000000002939" @default.
• W2472911856 startingPage "10.1212/WNL.0000000000002939" @default.
• W2472911856 abstract "<h3>Objective:</h3> The aims of the current study were to determine whether children with the 6 different <i>APOE</i> ε genotypes show differences in gray matter maturation, particularly for those with ε4 and ε2 alleles, which are associated with poorer outcomes in many neurologic disorders. <h3>Methods:</h3> A total of 1,187 healthy children (aged 3–20 years, 52.1% boys, 47.9% girls) with acceptable data from the cross-sectional Pediatric Imaging Neurocognition and Genetics Study were evaluated for the effects of 6 <i>APOE</i> ε genotypes on macroscopic and microscopic cortical and subcortical gray matter structures (measured with 3-tesla MRI and FreeSurfer for automated morphometry) and on cognition (NIH Toolbox). <h3>Results:</h3> Among <i>APOE</i> ε4 carriers, age-related changes in brain structures and cognition varied depending on genotype, with the smallest hippocampi in ε2ε4 children, the lowest hippocampal fractional anisotropy in younger ε4ε4 children, the largest medial orbitofrontal cortical areas in ε3ε4 children, and age-dependent thinning of the entorhinal cortex in ε4ε4 children. Younger ε4ε4 children had the lowest scores on executive function and working memory, while younger ε2ε4 children performed worse on attention tasks. Larger parietal gyri in the younger ε2ε4 children, and thinner temporal and cingulate isthmus cortices or smaller hippocampi in the younger ε4ε4 children, predicted poorer performance on attention or working memory. <h3>Conclusions:</h3> Our findings validated and extended prior smaller studies that showed altered brain development in <i>APOE</i> ε4–carrier children. The ε4ε4 and ε2ε4 genotypes may negatively influence brain development and brain aging at the extremes of age. Studying <i>APOE</i> ε polymorphisms in young children may provide the earliest indicators for individuals who might benefit from early interventions or preventive measures for future brain injuries and dementia." @default.
• W2472911856 created "2016-07-22" @default.
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• W2472911856 date "2016-07-13" @default.
• W2472911856 modified "2023-10-10" @default.
• W2472911856 title "Gray matter maturation and cognition in children with different<i>APOE</i>ε genotypes" @default.
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• W2472911856 doi "https://doi.org/10.1212/wnl.0000000000002939" @default.
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