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• W2472921962 abstract "Abstract Cochlear neuropathy resulting from unsafe noise exposure is a life altering condition that affects many people. This hearing dysfunction follows a conserved mechanism where inner hair cell synapses are lost, termed cochlear synaptopathy. Here we investigate cochlear synaptopathy in the FVB/nJ mouse strain as a prelude for the investigation of candidate genetic mutations for noise damage susceptibility. We used measurements of auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) to assess hearing recovery in FVB/nJ mice exposed to two different noise levels. We also utilized confocal fluorescence microscopy in mapped whole mount cochlear tissue, in conjunction with deconvolution and three-dimensional modeling, to analyze numbers, volumes and positions of paired synaptic components. We find evidence for significant synapse reorganization in response to both synaptopathic and sub-synaptopathic noise exposures in FVB/nJ. Specifically, we find that the modulation in volume of very small synaptic ribbons correlates with the presence of reduced ABR peak one amplitudes in both levels of noise exposures. These experiments define the use of FVB/nJ mice for further genetic investigations into the mechanisms of noise damage. They further suggest that in the cochlea, neuronal-inner hair cell connections may dynamically reshape as part of the noise response." @default.
• W2472921962 created "2016-07-22" @default.
• W2472921962 creator A5003985726 @default.
• W2472921962 creator A5043332995 @default.
• W2472921962 creator A5091391896 @default.
• W2472921962 date "2016-05-10" @default.
• W2472921962 modified "2023-10-17" @default.
• W2472921962 title "Noise exposure modulates cochlear inner hair cell ribbon volumes, correlating with changes in auditory measures in the FVB/nJ mouse" @default.
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• W2472921962 doi "https://doi.org/10.1038/srep25056" @default.
• W2472921962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4861931" @default.
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• W2472921962 hasPublicationYear "2016" @default.
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