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- W2472956178 abstract "AbstractJuvenile Laryngeal Papillomatosis – Immunisationwith the Polyvalent Vaccine Gardasil ˘ ! Juvenile laryngeal papillomatosis is a rare condition caused byhuman papilloma virus (HPV). In cases with rapid recurrencespermanent impairments of voice and breathing are almost in-evitable due to the frequent need of debulking surgeries. Effortsto lower the recurrence rate comprise the adjuvant use of inter-feron alpha, local cidofovir, photodynamic therapy or mumpsvaccination.In the present case we tried to positively influence the aggres-sive course of disease in a two year old boy by immunisationwith the quadrivalent HPV vaccine Gardasil ˘ . Chromogenicin-situ hybridisation analysis and polymerase chain reaction(PCR) of lesion tissue showed simultaneous infection with theHPV-Types 6 and 11. After the third immunisation the diseasebecame stable. No further surgery was necessary for the last tenmonths.The risk profile of this adjuvant treatment is low. We think itworth to initiate a multicentre trial to prove a benefit of thistreatmenteven if no complete virus elimination can be achieved." @default.
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- W2472956178 date "2008-01-01" @default.
- W2472956178 modified "2023-09-27" @default.
- W2472956178 title "Juvenile Larynxpapillomatose - Impfung mit dem polyvalenten Spaltimpfstoff Gardasil Juvenile Laryngeal Papillomatosis - Immunisation with the Polyvalent Vaccine Gardasil" @default.
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