FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2472984716> ?p ?o ?g. }

• W2472984716 endingPage "900" @default.
• W2472984716 startingPage "893" @default.
• W2472984716 abstract "To evaluate the long-term safety of rituximab (RTX) in rheumatoid arthritis (RA) patients in daily clinical practice.This was a multicentre (17 Greek Rheumatology sites), prospective, long-term, pharmacovigilance study of patients with moderate to severe RA and an inadequate response or intolerance to ≥1 anti-tumour necrosis factor (TNF) agents. Adverse events (AEs) were recorded and collected prospectively every 2-6 months.234 patients (mean age: 59±12.5, 79.5% women, mean DAS28: 5.35±1.32) were included and followed for 27.7 months (median). The overall AEs, serious AE (SAEs) and serious infection (SIEs) rate were 48.36, 6.68 and 2.53/100 patient-years, respectively. Three cases of hepatitis B virus (HBV) reactivation were recorded (two in chronic and one in past HBV infection). Withdrawals due to AEs (5.6%) occurred more frequently during the first cycles of RTX therapy while repeated RTX cycles were not associated with an increased risk of AEs. There were 3 deaths with an incidence rate of 0.69/100 patient-years. Age ≥65 years was associated with a higher incidence rate ratio of AEs and SAEs as compared to <65 years (1.53, p=0.002 and 2.88, p=0.005, respectively). Drug retention rate during 434.28 patient-years of follow-up was 57.3%. Factors associated with drug discontinuation by multivariate analysis included age, baseline swollen joint count and no use of concomitant methotrexate therapy.Long-term RTX therapy in a real-life RA cohort, did not reveal any new safety issues. Advanced age was associated with increased risk of AEs and premature drug discontinuation." @default.
• W2472984716 created "2016-07-22" @default.
• W2472984716 creator A5007341235 @default.
• W2472984716 creator A5007608312 @default.
• W2472984716 creator A5009772703 @default.
• W2472984716 creator A5017679486 @default.
• W2472984716 creator A5024273038 @default.
• W2472984716 creator A5028405912 @default.
• W2472984716 creator A5029036369 @default.
• W2472984716 creator A5029239105 @default.
• W2472984716 creator A5037301799 @default.
• W2472984716 creator A5039759199 @default.
• W2472984716 creator A5039944418 @default.
• W2472984716 creator A5041783670 @default.
• W2472984716 creator A5049153876 @default.
• W2472984716 creator A5052268446 @default.
• W2472984716 creator A5066611867 @default.
• W2472984716 creator A5067877587 @default.
• W2472984716 creator A5069064151 @default.
• W2472984716 creator A5070933999 @default.
• W2472984716 creator A5071905620 @default.
• W2472984716 date "2016-07-08" @default.
• W2472984716 modified "2023-09-27" @default.
• W2472984716 title "Safety profile of repeated rituximab cycles in unselected rheumatoid arthritis patients: a long-term, prospective real-life study." @default.
• W2472984716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27383049" @default.
• W2472984716 hasPublicationYear "2016" @default.
• W2472984716 type Work @default.
• W2472984716 sameAs 2472984716 @default.
• W2472984716 citedByCount "12" @default.
• W2472984716 countsByYear W24729847162017 @default.
• W2472984716 countsByYear W24729847162018 @default.
• W2472984716 countsByYear W24729847162019 @default.
• W2472984716 countsByYear W24729847162020 @default.
• W2472984716 countsByYear W24729847162021 @default.
• W2472984716 countsByYear W24729847162022 @default.
• W2472984716 countsByYear W24729847162023 @default.
• W2472984716 crossrefType "journal-article" @default.
• W2472984716 hasAuthorship W2472984716A5007341235 @default.
• W2472984716 hasAuthorship W2472984716A5007608312 @default.
• W2472984716 hasAuthorship W2472984716A5009772703 @default.
• W2472984716 hasAuthorship W2472984716A5017679486 @default.
• W2472984716 hasAuthorship W2472984716A5024273038 @default.
• W2472984716 hasAuthorship W2472984716A5028405912 @default.
• W2472984716 hasAuthorship W2472984716A5029036369 @default.
• W2472984716 hasAuthorship W2472984716A5029239105 @default.
• W2472984716 hasAuthorship W2472984716A5037301799 @default.
• W2472984716 hasAuthorship W2472984716A5039759199 @default.
• W2472984716 hasAuthorship W2472984716A5039944418 @default.
• W2472984716 hasAuthorship W2472984716A5041783670 @default.
• W2472984716 hasAuthorship W2472984716A5049153876 @default.
• W2472984716 hasAuthorship W2472984716A5052268446 @default.
• W2472984716 hasAuthorship W2472984716A5066611867 @default.
• W2472984716 hasAuthorship W2472984716A5067877587 @default.
• W2472984716 hasAuthorship W2472984716A5069064151 @default.
• W2472984716 hasAuthorship W2472984716A5070933999 @default.
• W2472984716 hasAuthorship W2472984716A5071905620 @default.
• W2472984716 hasConcept C120665830 @default.
• W2472984716 hasConcept C121332964 @default.
• W2472984716 hasConcept C126322002 @default.
• W2472984716 hasConcept C141071460 @default.
• W2472984716 hasConcept C188816634 @default.
• W2472984716 hasConcept C197934379 @default.
• W2472984716 hasConcept C2777178219 @default.
• W2472984716 hasConcept C2777575956 @default.
• W2472984716 hasConcept C2778715236 @default.
• W2472984716 hasConcept C2779338263 @default.
• W2472984716 hasConcept C2779384505 @default.
• W2472984716 hasConcept C2780653079 @default.
• W2472984716 hasConcept C61511704 @default.
• W2472984716 hasConcept C71924100 @default.
• W2472984716 hasConcept C90924648 @default.
• W2472984716 hasConceptScore W2472984716C120665830 @default.
• W2472984716 hasConceptScore W2472984716C121332964 @default.
• W2472984716 hasConceptScore W2472984716C126322002 @default.
• W2472984716 hasConceptScore W2472984716C141071460 @default.
• W2472984716 hasConceptScore W2472984716C188816634 @default.
• W2472984716 hasConceptScore W2472984716C197934379 @default.
• W2472984716 hasConceptScore W2472984716C2777178219 @default.
• W2472984716 hasConceptScore W2472984716C2777575956 @default.
• W2472984716 hasConceptScore W2472984716C2778715236 @default.
• W2472984716 hasConceptScore W2472984716C2779338263 @default.
• W2472984716 hasConceptScore W2472984716C2779384505 @default.
• W2472984716 hasConceptScore W2472984716C2780653079 @default.
• W2472984716 hasConceptScore W2472984716C61511704 @default.
• W2472984716 hasConceptScore W2472984716C71924100 @default.
• W2472984716 hasConceptScore W2472984716C90924648 @default.
• W2472984716 hasIssue "5" @default.
• W2472984716 hasLocation W24729847161 @default.
• W2472984716 hasOpenAccess W2472984716 @default.
• W2472984716 hasPrimaryLocation W24729847161 @default.
• W2472984716 hasRelatedWork W2050078649 @default.
• W2472984716 hasRelatedWork W2241415449 @default.
• W2472984716 hasRelatedWork W2313613548 @default.
• W2472984716 hasRelatedWork W2752495822 @default.
• W2472984716 hasRelatedWork W2755252346 @default.
• W2472984716 hasRelatedWork W2909197059 @default.
• W2472984716 hasRelatedWork W2918206885 @default.
• W2472984716 hasRelatedWork W3163909194 @default.

• next