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• W24730151 startingPage "H1462" @default.
• W24730151 abstract "We previously showed that in adult rat ventricular myocytes interleukin (IL)-1β activates a membrane-associated, Ca 2+ -independent phospholipase A 2 (iPLA 2 ). In this study, we examined the possible existence of different PLA 2 isoforms and effects of tumor necrosis factor (TNF)-α on iPLA 2 activities. Western blot analysis identified iPLA 2 in both membrane (∼82 kDa) and cytosolic (∼40 kDa) fractions and identified Ca 2+ -dependent PLA 2 (cPLA 2 ) only in cytosolic fractions. With plasmenylcholine or alkylacyl glycerophosphorylcholine as substrate, TNF-α elicited a twofold transient increase in cytosolic iPLA 2 activity accompanied by an increase in arachidonic acid release and decreased membrane-associated iPLA 2 activity with plasmenylcholine. With phosphatidylcholine as substrate, TNF-α decreased both cytosolic and membrane-associated iPLA 2 activities. TNF-α-induced increases in cytosolic iPLA 2 activity and arachidonic acid release were completely blocked by methyl arachidonyl fluorophosphonate (MAFP) but not by bromoenol lactone (BEL). TNF-α and IL-1β together enhanced synergistically cytosolic and membrane PLA 2 activities and arachidonic acid release that were blocked differentially by MAFP and BEL, respectively, and inhibited completely by MAFP plus BEL. These results suggest that TNF-α and IL-1β act on different PLA 2 isoforms in ventricular myocytes." @default.
• W24730151 created "2016-06-24" @default.
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• W24730151 creator A5033349808 @default.
• W24730151 date "1998-10-01" @default.
• W24730151 modified "2023-10-18" @default.
• W24730151 title "Stimulation of different phospholipase A₂isoforms by TNF-α and IL-1β in adult rat ventricular myocytes" @default.
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• W24730151 doi "https://doi.org/10.1152/ajpheart.1998.275.4.h1462" @default.
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