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- W2473071503 abstract "Abstract Background : Exposure to carbon dioxide (CO 2 ) gas as a killing method is aversive and exposure to high concentrations likely to be painful. Bradycardia during exposure to CO 2 is associated with nociception and pain. However, it is unclear if bradycardia occurs before loss of consciousness as this is variably defined in the literature. The objectives of this study were to explore the relationship between recumbency, loss of righting reflex (LORR) and a quiescent electromyograph as measures of loss of consciousness, and identify the onset of bradycardia in relation to these measures. Methods : Thirty-two adult, female Sprague-Dawley rats were instrumented with a telemetry device and randomly assigned to one of four killing methods (100% CO 2 , CO 2 (70%)/O 2 (30%), isoflurane (5%) and intraperitoneal pentobarbital (200 mg/kg). Time to achieve recumbency, LORR, quiescent electromyograph, isoelectric electrocorticograph, heart rate and apnea were recorded. Results : The general order of progression was recumbency, LORR, quiescent electromyograph, isoelectric electrocorticograph and apnea. Recumbency preceded LORR in the majority of animals (CO 2 ; 7/8, CO 2 /O 2 ; 8/8, isoflurane; 5/8, pentobarbital; 4/8). Bradycardia occurred before recumbency in the CO 2 (p = 0.0002) and CO 2 /O 2 (p = 0.005) groups, with a 50% reduction in heart rate compared to baseline. The slowest (time to apnea) and least consistent killing methods were CO 2 /O 2 (1180 ± 658.1s) and pentobarbital (875 [239 to 4680]s). Conclusion : Bradycardia, and consequently nociception and pain, occurs before loss of consciousness during CO 2 exposure. Pentobarbital displayed an unexpected lack of consistency, questioning its classification as an acceptable euthanasia method in rats." @default.
- W2473071503 created "2016-07-22" @default.
- W2473071503 creator A5036290093 @default.
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- W2473071503 date "2016-06-28" @default.
- W2473071503 modified "2023-10-14" @default.
- W2473071503 title "Assessment of carbon dioxide, carbon dioxide/oxygen, isoflurane and pentobarbital killing methods in rats" @default.
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- W2473071503 doi "https://doi.org/10.1101/061002" @default.
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