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- W2473119447 endingPage "330" @default.
- W2473119447 startingPage "303" @default.
- W2473119447 abstract "Abstract Nanoindentation allows quantitative determination of a material’s response to stress such as elastic and plastic deformation or fracture tendency. Key instruments that have enabled great advances in nanomechanical studies are the instrumented nanoindenter and atomic force microscopy. The versatility of these instruments lies in their capability to measure local mechanical response, in very small volumes and depths, while monitoring time, displacement and force with high accuracy and precision. This review highlights the application of nanoindentation for mechanical characterization of pharmaceutical materials in the preformulation phase (primary investigation of crystalline active ingredients and excipients). With nanoindentation, mechanical response can be assessed with respect to crystal structure. The technique is valuable for mechanical screening of a material at an early development phase in order to predict and better control the processes in which a material is exposed to stress such as milling and compression." @default.
- W2473119447 created "2016-07-22" @default.
- W2473119447 creator A5053837298 @default.
- W2473119447 creator A5054143787 @default.
- W2473119447 creator A5081447282 @default.
- W2473119447 date "2016-06-29" @default.
- W2473119447 modified "2023-09-30" @default.
- W2473119447 title "Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients" @default.
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- W2473119447 doi "https://doi.org/10.1515/acph-2016-0032" @default.
- W2473119447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27383883" @default.