FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2473119987> ?p ?o ?g. }

• W2473119987 endingPage "481e" @default.
• W2473119987 startingPage "480e" @default.
• W2473119987 abstract "Sir: We read with great interest the article by Yun and colleagues.1 We congratulate the authors for their work, which may be a prelude to the clinical application of heat shock protein 90 (HSP90) inhibitors for keloid treatment. We would like to discuss this topic to add a further piece to the pathogenic “puzzle” underlying keloids formation and the authors’ findings. Toll-like receptor 4 (TLR4) is a transmembrane protein expressed by inflammatory cells, fibroblasts, and keratinocytes. It binds to exogenous ligands, such as lipopolysaccharide, and to endogenous ones, such as heat shock proteins and fibronectin. Physiologically, it plays a role as a biosensor of tissue damage and sterile inflammation to initiate tissue repair after injury. Nevertheless, TLR4 is overexpressed in pathologic fibroses, such as keloids,2 and increases transforming growth factor (TGF)-β signaling, responses, and fibroblast activation and proliferation.3 The interaction between HSP90 and TLR4 has recently been investigated in other tissues. Thuringer and colleagues found that HSP90 administration induced TLR4 activation. In contrast, specific inhibition of TLR4 expression suppressed extracellular HSP90-induced signaling and associated cell migration.4 Moreover, 17-allylaminodemethoxygeldanamycin (which is the same HSP90 inhibitor investigated by Yun et al.1) was found to block the proinflammatory TLR4 activation.5 Considered together, these findings provide consistent evidence of a close interaction between HSP90 and TLR4, with the first being a major cofactor in the onset of TLR4 intracellular pathways. In a stress condition, such as wound healing after surgery or trauma, the increase in HSP90 and the induction of TLR4 signaling may induce fibroblast activation, proliferation, and migration in addition to higher TGF-β production and responsiveness. As a consequence, a self-amplifying loop develops, sustaining both cellular proliferation and collagen overproduction. In their work, the authors found that 17-allylaminodemethoxygeldanamycin induces apoptosis and decreases cell migration/mobility of keloid fibroblasts. It would be interesting to assess collagen types I/III, fibronectin production, and TLR4 activation in the experimental group compared with the control group. HSP90 may act at different levels to promote cell proliferation and migration: we would like to encourage the authors to further investigate the role of HSP90 inhibition and its possible relationship with TLR4 signaling in future studies. Keloids still represent a major challenge for plastic surgeons. Thus, we appreciate this innovative article and are deeply interested in the translational application of the authors’ findings. DISCLOSURE The authors have no financial interest to declare in relation to the content of this communication. Francesco Segreto, M.D. Giovanni Francesco Marangi, M.D., Ph.D. Pierluigi Gigliofiorito, M.D. Francesca Briganti, M.S. Paolo Persichetti, M.D., Ph.D. Department of Plastic, Reconstructive and Aesthetic Surgery “Campus Bio-Medico di Roma” University Rome, Italy" @default.
• W2473119987 created "2016-07-22" @default.
• W2473119987 creator A5020330551 @default.
• W2473119987 creator A5047139739 @default.
• W2473119987 creator A5060613972 @default.
• W2473119987 creator A5068375156 @default.
• W2473119987 creator A5069054589 @default.
• W2473119987 date "2016-02-01" @default.
• W2473119987 modified "2023-09-27" @default.
• W2473119987 title "HSP90 and TLR4 Interplay in Keloids" @default.
• W2473119987 cites W1991925601 @default.
• W2473119987 cites W20377036 @default.
• W2473119987 cites W2041174049 @default.
• W2473119987 cites W2157879652 @default.
• W2473119987 cites W2403216479 @default.
• W2473119987 doi "https://doi.org/10.1097/01.prs.0000475819.81154.81" @default.
• W2473119987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26818343" @default.
• W2473119987 hasPublicationYear "2016" @default.
• W2473119987 type Work @default.
• W2473119987 sameAs 2473119987 @default.
• W2473119987 citedByCount "2" @default.
• W2473119987 countsByYear W24731199872021 @default.
• W2473119987 countsByYear W24731199872023 @default.
• W2473119987 crossrefType "journal-article" @default.
• W2473119987 hasAuthorship W2473119987A5020330551 @default.
• W2473119987 hasAuthorship W2473119987A5047139739 @default.
• W2473119987 hasAuthorship W2473119987A5060613972 @default.
• W2473119987 hasAuthorship W2473119987A5068375156 @default.
• W2473119987 hasAuthorship W2473119987A5069054589 @default.
• W2473119987 hasConcept C104317684 @default.
• W2473119987 hasConcept C126322002 @default.
• W2473119987 hasConcept C142724271 @default.
• W2473119987 hasConcept C164027704 @default.
• W2473119987 hasConcept C170493617 @default.
• W2473119987 hasConcept C189165786 @default.
• W2473119987 hasConcept C203014093 @default.
• W2473119987 hasConcept C205260736 @default.
• W2473119987 hasConcept C2775932338 @default.
• W2473119987 hasConcept C2776070231 @default.
• W2473119987 hasConcept C2776914184 @default.
• W2473119987 hasConcept C2777538232 @default.
• W2473119987 hasConcept C2780269544 @default.
• W2473119987 hasConcept C2780381497 @default.
• W2473119987 hasConcept C28406088 @default.
• W2473119987 hasConcept C502942594 @default.
• W2473119987 hasConcept C54355233 @default.
• W2473119987 hasConcept C55493867 @default.
• W2473119987 hasConcept C62478195 @default.
• W2473119987 hasConcept C71924100 @default.
• W2473119987 hasConcept C79879829 @default.
• W2473119987 hasConcept C81885089 @default.
• W2473119987 hasConcept C86492073 @default.
• W2473119987 hasConcept C86803240 @default.
• W2473119987 hasConcept C95444343 @default.
• W2473119987 hasConceptScore W2473119987C104317684 @default.
• W2473119987 hasConceptScore W2473119987C126322002 @default.
• W2473119987 hasConceptScore W2473119987C142724271 @default.
• W2473119987 hasConceptScore W2473119987C164027704 @default.
• W2473119987 hasConceptScore W2473119987C170493617 @default.
• W2473119987 hasConceptScore W2473119987C189165786 @default.
• W2473119987 hasConceptScore W2473119987C203014093 @default.
• W2473119987 hasConceptScore W2473119987C205260736 @default.
• W2473119987 hasConceptScore W2473119987C2775932338 @default.
• W2473119987 hasConceptScore W2473119987C2776070231 @default.
• W2473119987 hasConceptScore W2473119987C2776914184 @default.
• W2473119987 hasConceptScore W2473119987C2777538232 @default.
• W2473119987 hasConceptScore W2473119987C2780269544 @default.
• W2473119987 hasConceptScore W2473119987C2780381497 @default.
• W2473119987 hasConceptScore W2473119987C28406088 @default.
• W2473119987 hasConceptScore W2473119987C502942594 @default.
• W2473119987 hasConceptScore W2473119987C54355233 @default.
• W2473119987 hasConceptScore W2473119987C55493867 @default.
• W2473119987 hasConceptScore W2473119987C62478195 @default.
• W2473119987 hasConceptScore W2473119987C71924100 @default.
• W2473119987 hasConceptScore W2473119987C79879829 @default.
• W2473119987 hasConceptScore W2473119987C81885089 @default.
• W2473119987 hasConceptScore W2473119987C86492073 @default.
• W2473119987 hasConceptScore W2473119987C86803240 @default.
• W2473119987 hasConceptScore W2473119987C95444343 @default.
• W2473119987 hasIssue "2" @default.
• W2473119987 hasLocation W24731199871 @default.
• W2473119987 hasOpenAccess W2473119987 @default.
• W2473119987 hasPrimaryLocation W24731199871 @default.
• W2473119987 hasRelatedWork W1513368991 @default.
• W2473119987 hasRelatedWork W1841506002 @default.
• W2473119987 hasRelatedWork W2019119875 @default.
• W2473119987 hasRelatedWork W2023320256 @default.
• W2473119987 hasRelatedWork W2040010734 @default.
• W2473119987 hasRelatedWork W2105826529 @default.
• W2473119987 hasRelatedWork W2136469540 @default.
• W2473119987 hasRelatedWork W2797952716 @default.
• W2473119987 hasRelatedWork W3195068827 @default.
• W2473119987 hasRelatedWork W4230030239 @default.
• W2473119987 hasVolume "137" @default.
• W2473119987 isParatext "false" @default.
• W2473119987 isRetracted "false" @default.
• W2473119987 magId "2473119987" @default.
• W2473119987 workType "article" @default.