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• W2473203208 abstract "The crucian carp (Carassius carassius) has an exceptional ability to tolerate anoxia, being able to survive without oxygen for several months at low temperatures. In response to low oxygen levels the crucian carp reduces its metabolic rate, and up-regulates glycolysis to produce enough ATP to fuel cellular ATP demand. These adaptations solve the main problem encountered during anoxia, which is to supply cells with enough ATP. The brain has a very high rate of ATP use, and it is therefore especially vulnerable during anoxic conditions. In the brain of mammals, even brief periods of oxygen deprivation can induce apoptotic cell death. It is still not known if the crucian carp brain suffers brain damage after anoxic exposure. The aim of this study was therefore to examine if anoxia, and/or subsequent reoxygenation, affect the incidence of apoptotic cell death in the brain of crucian carp. The terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) method was applied to stain for and quantify apoptotic cells in the crucian carp telencephalon. The amount of apoptotic cells did not increase significantly after 7 days of anoxia (at 9 °C). However, when the anoxic fish were given 1 day of reoxygenation at normal oxygen levels, a 170 % increase in the number of apoptotic cells was detected. The elevated apoptosis after reoxygenation resembles the effect of reperfusion after cerebral ischemia in mammals, where reperfusion accelerates the rate of cell death. One possibility is that anoxia initiates apoptotic pathways in the brain without leading to actual cell death until oxygen is restored. Another possibility is that anoxia in itself does not induce apoptosis, but that the following reoxygenation causes increased apoptosis. Regardless, anoxia followed by reoxygenation does cause some damage in the form of increased levels of apoptosis in the crucian carp telencephalon. This points at an hitherto unrecognized aspect of anoxia tolerance in crucian carp: the need to possess effective mechanisms to repair a damaged brain after anoxia / reoxygenation events." @default.
• W2473203208 created "2016-07-22" @default.
• W2473203208 creator A5033702758 @default.
• W2473203208 date "2010-01-01" @default.
• W2473203208 modified "2023-09-27" @default.
• W2473203208 title "Anoxia / reoxygenation induced cell death in crucian carp brain" @default.
• W2473203208 cites W129343397 @default.
• W2473203208 cites W1545921426 @default.
• W2473203208 cites W1591176056 @default.
• W2473203208 cites W1603358355 @default.
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• W2473203208 cites W1937717811 @default.
• W2473203208 cites W1966169165 @default.
• W2473203208 cites W1967499593 @default.
• W2473203208 cites W1972476325 @default.
• W2473203208 cites W1973205178 @default.
• W2473203208 cites W1976513308 @default.
• W2473203208 cites W1979747886 @default.
• W2473203208 cites W1979782843 @default.
• W2473203208 cites W1983502376 @default.
• W2473203208 cites W1984990667 @default.
• W2473203208 cites W1986449271 @default.
• W2473203208 cites W1990269235 @default.
• W2473203208 cites W1992527837 @default.
• W2473203208 cites W1993224545 @default.
• W2473203208 cites W1996955969 @default.
• W2473203208 cites W1998732967 @default.
• W2473203208 cites W2002273297 @default.
• W2473203208 cites W2002696533 @default.
• W2473203208 cites W2004850139 @default.
• W2473203208 cites W2005093873 @default.
• W2473203208 cites W2007179226 @default.
• W2473203208 cites W2008757142 @default.
• W2473203208 cites W2009771084 @default.
• W2473203208 cites W2010578513 @default.
• W2473203208 cites W2014054785 @default.
• W2473203208 cites W2016331817 @default.
• W2473203208 cites W2016402579 @default.
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• W2473203208 cites W2025955916 @default.
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• W2473203208 cites W2031675072 @default.
• W2473203208 cites W2035773751 @default.
• W2473203208 cites W2036318922 @default.
• W2473203208 cites W2036873456 @default.
• W2473203208 cites W2050758798 @default.
• W2473203208 cites W2050830063 @default.
• W2473203208 cites W2052109950 @default.
• W2473203208 cites W2052581507 @default.
• W2473203208 cites W2052853635 @default.
• W2473203208 cites W2053204649 @default.
• W2473203208 cites W2053518665 @default.
• W2473203208 cites W2057662062 @default.
• W2473203208 cites W2058643007 @default.
• W2473203208 cites W2060133312 @default.
• W2473203208 cites W2067443777 @default.
• W2473203208 cites W2069915122 @default.
• W2473203208 cites W2078861609 @default.
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• W2473203208 cites W2092808670 @default.
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• W2473203208 cites W2099379562 @default.
• W2473203208 cites W2103278596 @default.
• W2473203208 cites W2103906636 @default.
• W2473203208 cites W2106624063 @default.
• W2473203208 cites W2119041240 @default.
• W2473203208 cites W2120992133 @default.
• W2473203208 cites W2125544838 @default.
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• W2473203208 cites W2131884667 @default.
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• W2473203208 cites W2155947670 @default.
• W2473203208 cites W2162672064 @default.
• W2473203208 cites W2184366236 @default.
• W2473203208 cites W2189360231 @default.
• W2473203208 cites W2254772549 @default.
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• W2473203208 cites W2281835866 @default.
• W2473203208 cites W2467946444 @default.
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• W2473203208 hasPublicationYear "2010" @default.
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