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- W2473204564 abstract "Parkinson’s disease (PD) at cellular level is characterized by selective death of dopamine neurons in nigral pars compacta. The type of cell death remains an enigma, even though recent results suggest that apoptosis may be a common type of cell death. Since the discovery of a neurotoxin selective to dopamine neurons, l-methyl-4-phenyl-1, 2, 3, 6-tetrahydro-pyridine (MPTP), various types of animal and cell models have been proposed to clarify the pathogenesis of PD. In this paper, an endogenous dopaminergic neurotoxin, N-methyl-(R)salsolinol [NM(R)Sal] was used to prepare the animal and cell models, and the mechanism underlying the selective degeneration of dopamine neurons was studied. By use of the cell model, a series of (-)deprenyl (selegiline) related propargylamines showed neuroprotective functions against apoptosis induced by the neurotoxin. These results are discussed in relation to the validity of animal and cell models in the study of PD and related neurodegenerative disorders.KeywordsCell ModelDopamine NeuronSelective DegenerationParkinsonian BrainSelective DeathThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W2473204564 created "2016-07-22" @default.
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- W2473204564 date "2002-01-01" @default.
- W2473204564 modified "2023-09-27" @default.
- W2473204564 title "Models of Parkinson’s Disease" @default.
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- W2473204564 doi "https://doi.org/10.1007/978-1-4757-3538-3_114" @default.
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