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- W2473251246 abstract "Acute myelogenous leukemia (AML) is a disease more common in older patients than in the young. It is increasingly recognized that conventional cytotoxic chemotherapies used in children and young adults may not be appropriate in older adults because of diverse host- and disease-biology factors. This review highlights some of the most promising new treatment options that are being evaluated for older patients with AML. These options include CPX-351 (Celator Pharmaceuticals Inc), a unique liposomal formulation of a fixed ratio of cytarabine and daunorubicin; timed sequential therapy with the CDK inhibitor alvocidib (flavopiridol; sanofi-aventis/NCI); the second-generation purine nucleoside analog clofarabine; the farnesyltransferase inhibitor tipifarnib (Johnson & Johnson Pharmaceutical Research and Development LLC); and the DNA methyltransferase inhibitors decitabine and azacitidine." @default.
- W2473251246 created "2016-07-22" @default.
- W2473251246 creator A5040758762 @default.
- W2473251246 creator A5061303658 @default.
- W2473251246 date "2010-06-01" @default.
- W2473251246 modified "2023-09-23" @default.
- W2473251246 title "Development of therapeutic agents for older patients with acute myelogenous leukemia." @default.
- W2473251246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4699173" @default.
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- W2473251246 hasPublicationYear "2010" @default.
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