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- W2473268164 abstract "Durable antibody production after vaccination or infection is mediated by long-lived plasma cells (LLPCs). Pathways that specifically allow LLPCs to persist remain unknown. Through bioenergetic profiling, we found that human and mouse LLPCs could robustly engage pyruvate-dependent respiration, whereas their short-lived counterparts could not. LLPCs took up more glucose than did short-lived plasma cells (SLPCs) in vivo, and this glucose was essential for the generation of pyruvate. Glucose was primarily used to glycosylate antibodies, but glycolysis could be promoted by stimuli such as low ATP levels and the resultant pyruvate used for respiration by LLPCs. Deletion of Mpc2, which encodes an essential component of the mitochondrial pyruvate carrier, led to a progressive loss of LLPCs and of vaccine-specific antibodies in vivo. Thus, glucose uptake and mitochondrial pyruvate import prevent bioenergetic crises and allow LLPCs to persist. Immunizations that maximize these plasma cell metabolic properties might thus provide enduring antibody-mediated immunity." @default.
- W2473268164 created "2016-07-22" @default.
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- W2473268164 date "2016-07-01" @default.
- W2473268164 modified "2023-10-17" @default.
- W2473268164 title "Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells" @default.
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- W2473268164 cites W1926727282 @default.
- W2473268164 cites W1932780354 @default.
- W2473268164 cites W1932854961 @default.
- W2473268164 cites W1969400861 @default.
- W2473268164 cites W1971068808 @default.
- W2473268164 cites W1971473212 @default.
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- W2473268164 cites W2168941586 @default.
- W2473268164 cites W2171674055 @default.
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- W2473268164 doi "https://doi.org/10.1016/j.immuni.2016.06.011" @default.
- W2473268164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4956536" @default.
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- W2473268164 hasPublicationYear "2016" @default.
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