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- W2473340369 abstract "Despite recent developments and treatment successes, the outcome, and prognosis of patients with lupus nephritis (LuN) have not greatly changed since the 1980s. This review covers the application of new concepts to the understanding of renal inflammation and the study of new pharmacologic agents to improve patient outcomes.Studies have shown that the presence of anti-vimentin antibodies and T follicular helper cells in patient biopsies is associated with more severe interstitial inflammation, which has been tied to faster disease progression and onset of end-stage renal disease. Additionally, data regarding the role of serum IgE antidouble-stranded DNA antibodies in LuN by means of mediating IFN1 production by plasmacytoid dendritic cells are highlighted. Finally, a thorough review of completed and currently open clinical trials of therapeutic agents is provided.Current management of LuN is guided almost exclusively by glomerular involvement. Based on the data provided in this review, we argue that renal tubulointerstitial inflammation is no less important and represents an overlooked feature in the current clinical approach to patients. Tubulointerstitial inflammation is driven by both adaptive and innate immune mechanisms that are still poorly understood. Studying these pathogenic processes promises to reveal new therapeutic opportunities for those LuN patients with the worst prognosis.Alternate video abstract introduction (see Video, Supplemental Digital Content 1, with introduction by two of the authors - VL and KT). Abstract Video: http://links.lww.com/COR/A35." @default.
- W2473340369 created "2016-07-22" @default.
- W2473340369 creator A5005445328 @default.
- W2473340369 creator A5027395645 @default.
- W2473340369 creator A5077742151 @default.
- W2473340369 date "2016-09-01" @default.
- W2473340369 modified "2023-10-16" @default.
- W2473340369 title "Overview of pathophysiology and treatment of human lupus nephritis" @default.
- W2473340369 cites W106396499 @default.
- W2473340369 cites W1625166229 @default.
- W2473340369 cites W1688265474 @default.
- W2473340369 cites W171428924 @default.
- W2473340369 cites W1759757419 @default.
- W2473340369 cites W1807019775 @default.
- W2473340369 cites W1856900646 @default.
- W2473340369 cites W1891725391 @default.
- W2473340369 cites W1913780655 @default.
- W2473340369 cites W1938487222 @default.
- W2473340369 cites W1963756694 @default.
- W2473340369 cites W1975548815 @default.
- W2473340369 cites W1981088341 @default.
- W2473340369 cites W1989273660 @default.
- W2473340369 cites W1996592861 @default.
- W2473340369 cites W1996845474 @default.
- W2473340369 cites W1999755139 @default.
- W2473340369 cites W2018384883 @default.
- W2473340369 cites W2018624539 @default.
- W2473340369 cites W2019873845 @default.
- W2473340369 cites W2023637057 @default.
- W2473340369 cites W2023960709 @default.
- W2473340369 cites W2025529696 @default.
- W2473340369 cites W2036018535 @default.
- W2473340369 cites W2036031491 @default.
- W2473340369 cites W2047328605 @default.
- W2473340369 cites W2048020812 @default.
- W2473340369 cites W2052010511 @default.
- W2473340369 cites W2061724257 @default.
- W2473340369 cites W2063960165 @default.
- W2473340369 cites W2066520348 @default.
- W2473340369 cites W2068121948 @default.
- W2473340369 cites W2069648600 @default.
- W2473340369 cites W2073246129 @default.
- W2473340369 cites W2075476600 @default.
- W2473340369 cites W2080882856 @default.
- W2473340369 cites W2082892740 @default.
- W2473340369 cites W2088037820 @default.
- W2473340369 cites W2089863875 @default.
- W2473340369 cites W2092568118 @default.
- W2473340369 cites W2094424038 @default.
- W2473340369 cites W2094907328 @default.
- W2473340369 cites W2095337395 @default.
- W2473340369 cites W2096194879 @default.
- W2473340369 cites W2098041182 @default.
- W2473340369 cites W2098881967 @default.
- W2473340369 cites W2101617710 @default.
- W2473340369 cites W2107871522 @default.
- W2473340369 cites W2110720586 @default.
- W2473340369 cites W2111940985 @default.
- W2473340369 cites W2115165922 @default.
- W2473340369 cites W2119373925 @default.
- W2473340369 cites W2119837784 @default.
- W2473340369 cites W2121136993 @default.
- W2473340369 cites W2121247695 @default.
- W2473340369 cites W2123082276 @default.
- W2473340369 cites W2123602540 @default.
- W2473340369 cites W2126846485 @default.
- W2473340369 cites W2127527121 @default.
- W2473340369 cites W2128331197 @default.
- W2473340369 cites W2130077869 @default.
- W2473340369 cites W2131457901 @default.
- W2473340369 cites W2133736867 @default.
- W2473340369 cites W2136149088 @default.
- W2473340369 cites W2141455950 @default.
- W2473340369 cites W2148880753 @default.
- W2473340369 cites W2148977472 @default.
- W2473340369 cites W2149459259 @default.
- W2473340369 cites W2149686068 @default.
- W2473340369 cites W2153970568 @default.
- W2473340369 cites W2157239580 @default.
- W2473340369 cites W2157322085 @default.
- W2473340369 cites W2160388191 @default.
- W2473340369 cites W2160445187 @default.
- W2473340369 cites W2161335088 @default.
- W2473340369 cites W2161537704 @default.
- W2473340369 cites W2162452494 @default.
- W2473340369 cites W2163649713 @default.
- W2473340369 cites W2165643073 @default.
- W2473340369 cites W2165909284 @default.
- W2473340369 cites W2168784022 @default.
- W2473340369 cites W2171121999 @default.
- W2473340369 cites W2227968444 @default.
- W2473340369 cites W2268416727 @default.
- W2473340369 cites W2285203686 @default.
- W2473340369 cites W2325870812 @default.
- W2473340369 cites W2404756824 @default.
- W2473340369 cites W2409438019 @default.
- W2473340369 cites W2469023517 @default.
- W2473340369 cites W271729629 @default.