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- W2473461569 endingPage "21" @default.
- W2473461569 startingPage "21" @default.
- W2473461569 abstract "Transforming growth factor beta (TGFβ) signalling is essential for wound healing, including both non-specific scar formation and tissue-specific regeneration. Specific TGFβ isoforms and downstream mediators of canonical and non-canonical signalling play different roles in each of these processes. Here we review the role of TGFβ signalling during tissue repair, with a particular focus on the prototypic isoforms TGFβ1, TGFβ2, and TGFβ3. We begin by introducing TGFβ signalling and then discuss the role of these growth factors and their key downstream signalling mediators in determining the balance between scar formation and tissue regeneration. Next we discuss examples of the pleiotropic roles of TGFβ ligands during cutaneous wound healing and blastema-mediated regeneration, and how inhibition of the canonical signalling pathway (using small molecule inhibitors) blocks regeneration. Finally, we review various TGFβ-targeting therapeutic strategies that hold promise for enhancing tissue repair." @default.
- W2473461569 created "2016-07-22" @default.
- W2473461569 creator A5010826689 @default.
- W2473461569 creator A5018738783 @default.
- W2473461569 creator A5090948337 @default.
- W2473461569 date "2016-06-22" @default.
- W2473461569 modified "2023-10-15" @default.
- W2473461569 title "Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration" @default.
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