Matches in SemOpenAlex for { <https://semopenalex.org/work/W2473589544> ?p ?o ?g. }
- W2473589544 endingPage "237" @default.
- W2473589544 startingPage "199" @default.
- W2473589544 abstract "Histone deacetylase inhibitors (HDACIs) are epigenetically acting agents that modify chromatin structure and by extension, gene expression. However, they may influence the behavior and survival of transformed cells by diverse mechanisms, including promoting expression of death- or differentiation-inducing genes while downregulating the expression of prosurvival genes; acting directly to increase oxidative injury and DNA damage; acetylating and disrupting the function of multiple proteins, including DNA repair and chaperone proteins; and interfering with the function of corepressor complexes. Notably, HDACIs have been shown in preclinical studies to target transformed cells selectively, and these agents have been approved in the treatment of certain hematologic malignancies, for example, cutaneous T-cell lymphoma and peripheral T-cell lymphoma. However, attempts to extend the spectrum of HDACI activity to other malignancies, for example, solid tumors, have been challenging. This has led to the perception that HDACIs may have limited activity as single agents. Because of the pleiotropic actions of HDACIs, combinations with other antineoplastic drugs, particularly other targeted agents, represent a particularly promising avenue of investigation. It is likely that emerging insights into mechanism(s) of HDACI activity will allow optimization of this approach, and hopefully, will expand HDACI approvals to additional malignancies in the future." @default.
- W2473589544 created "2016-07-22" @default.
- W2473589544 creator A5029125895 @default.
- W2473589544 creator A5061036144 @default.
- W2473589544 date "2012-01-01" @default.
- W2473589544 modified "2023-09-30" @default.
- W2473589544 title "Histone Deacetylase Inhibitors and Rational Combination Therapies" @default.
- W2473589544 cites W1484293540 @default.
- W2473589544 cites W1495058242 @default.
- W2473589544 cites W1498135837 @default.
- W2473589544 cites W1535444616 @default.
- W2473589544 cites W1538880474 @default.
- W2473589544 cites W1538955534 @default.
- W2473589544 cites W1929921628 @default.
- W2473589544 cites W1965239527 @default.
- W2473589544 cites W1965703240 @default.
- W2473589544 cites W1968948902 @default.
- W2473589544 cites W1970962289 @default.
- W2473589544 cites W1972149587 @default.
- W2473589544 cites W1973109581 @default.
- W2473589544 cites W1974090542 @default.
- W2473589544 cites W1974167857 @default.
- W2473589544 cites W1974277276 @default.
- W2473589544 cites W1975468616 @default.
- W2473589544 cites W1975692560 @default.
- W2473589544 cites W1976385326 @default.
- W2473589544 cites W1976470813 @default.
- W2473589544 cites W1976888700 @default.
- W2473589544 cites W1978567987 @default.
- W2473589544 cites W1984252723 @default.
- W2473589544 cites W1986938005 @default.
- W2473589544 cites W1988109163 @default.
- W2473589544 cites W1988466148 @default.
- W2473589544 cites W1990801507 @default.
- W2473589544 cites W1991054314 @default.
- W2473589544 cites W1991234705 @default.
- W2473589544 cites W1991478260 @default.
- W2473589544 cites W1991689978 @default.
- W2473589544 cites W1992672293 @default.
- W2473589544 cites W1995563061 @default.
- W2473589544 cites W1996809397 @default.
- W2473589544 cites W1997671473 @default.
- W2473589544 cites W1999247085 @default.
- W2473589544 cites W2001465534 @default.
- W2473589544 cites W2003907016 @default.
- W2473589544 cites W2004088511 @default.
- W2473589544 cites W2004335766 @default.
- W2473589544 cites W2004800182 @default.
- W2473589544 cites W2004800205 @default.
- W2473589544 cites W2004980848 @default.
- W2473589544 cites W2006450622 @default.
- W2473589544 cites W2006690126 @default.
- W2473589544 cites W2006864891 @default.
- W2473589544 cites W2007773961 @default.
- W2473589544 cites W2008650297 @default.
- W2473589544 cites W2010140285 @default.
- W2473589544 cites W2012393031 @default.
- W2473589544 cites W2013715448 @default.
- W2473589544 cites W2014599726 @default.
- W2473589544 cites W2014652020 @default.
- W2473589544 cites W2016770760 @default.
- W2473589544 cites W2017608962 @default.
- W2473589544 cites W2018313485 @default.
- W2473589544 cites W2020621201 @default.
- W2473589544 cites W2020677165 @default.
- W2473589544 cites W2021198013 @default.
- W2473589544 cites W2026004604 @default.
- W2473589544 cites W2026421375 @default.
- W2473589544 cites W2028959659 @default.
- W2473589544 cites W2031671750 @default.
- W2473589544 cites W2032183631 @default.
- W2473589544 cites W2032204792 @default.
- W2473589544 cites W2034420402 @default.
- W2473589544 cites W2036734119 @default.
- W2473589544 cites W2038118195 @default.
- W2473589544 cites W2039278049 @default.
- W2473589544 cites W2040255124 @default.
- W2473589544 cites W2040512018 @default.
- W2473589544 cites W2042322422 @default.
- W2473589544 cites W2042985720 @default.
- W2473589544 cites W2044365745 @default.
- W2473589544 cites W2046982014 @default.
- W2473589544 cites W2047542386 @default.
- W2473589544 cites W2051890772 @default.
- W2473589544 cites W2052021505 @default.
- W2473589544 cites W2053290453 @default.
- W2473589544 cites W2053344100 @default.
- W2473589544 cites W2053510126 @default.
- W2473589544 cites W2054711162 @default.
- W2473589544 cites W2057065967 @default.
- W2473589544 cites W2059002036 @default.
- W2473589544 cites W2060794068 @default.
- W2473589544 cites W2061195629 @default.
- W2473589544 cites W2062424910 @default.
- W2473589544 cites W2062602336 @default.
- W2473589544 cites W2065841250 @default.
- W2473589544 cites W2067432529 @default.
- W2473589544 cites W2067692987 @default.