FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2473611361> ?p ?o ?g. }

• W2473611361 abstract "Background: Fleas are the most common ectoparasite infesting dogs globally. The many possible sequellae of infestation include: direct discomfort; allergic reactions; and the transmission of pathogens. Rapid speed of kill is an important characteristic for a parasiticide in order to alleviate the direct deleterious effects of fleas, reduce the impact of allergic responses, and break the flea infestation cycle. In this study, the speed of kill of a novel orally administered isoxazoline parasiticide, sarolaner (Simparica ™ ) against fleas on dogs was evaluated and compared with afoxolaner (NexGard ® ) for 5 weeks after a single oral dose. Methods: Twenty-four dogs were randomly allocated to treatment with a single oral dose at label rate of either sarolaner (2 to 4 mg/kg) or afoxolaner (2.5 to 6.8 mg/kg) or placebo, based on pretreatment flea counts. Dogs were combed and live fleas counted at 8, 12 and 24 h after treatment and subsequent re-infestations on Days 7, 14, 21, 28 and 35. Efficacy was determined at each time point relative to counts for placebo dogs. Results: There were no adverse reactions to treatment. A single oral dose of sarolaner provided ≥98.8 % efficacy (based on geometric means) within 8 h of treatment or subsequent weekly re-infestations of fleas to Day 35. By 12 h, fleas were virtually eradicated from all dogs, with only two fleas recovered from a single sarolaner-treated dog on Day 7; efficacy was 100 % at all other time points. Significantly greater numbers of live fleas were recovered from afoxolaner-treated dogs at 8 h on all days and at 12 h on Days 28 and 35 (P< 0.05). Conclusions: In this controlled laboratory evaluation, sarolaner had a significantly faster speed of kill against fleas than afoxolaner. This was noticeably more evident towards the end of the treatment period. The rapid and consistent kill of fleas within 8 to 12 h after a single oral dose of sarolaner over 35 days indicates that this treatment will provide highly effective control of flea infestations, relief for dogs afflicted with flea allergy dermatitis, and should reduce the risk of flea-borne pathogen transmission." @default.
• W2473611361 created "2016-07-22" @default.
• W2473611361 creator A5033224530 @default.
• W2473611361 creator A5053715070 @default.
• W2473611361 creator A5079589829 @default.
• W2473611361 creator A5082317086 @default.
• W2473611361 date "2016-01-01" @default.
• W2473611361 modified "2023-09-27" @default.
• W2473611361 title "against induced infestations of Ctenocephalides felis on dogs" @default.
• W2473611361 cites W1509848853 @default.
• W2473611361 cites W1577393878 @default.
• W2473611361 cites W179337071 @default.
• W2473611361 cites W1841369928 @default.
• W2473611361 cites W1972560655 @default.
• W2473611361 cites W1978980996 @default.
• W2473611361 cites W2031168859 @default.
• W2473611361 cites W2063889049 @default.
• W2473611361 cites W2066014580 @default.
• W2473611361 cites W2076149628 @default.
• W2473611361 cites W2095540646 @default.
• W2473611361 cites W2096297270 @default.
• W2473611361 cites W2108667965 @default.
• W2473611361 cites W2111202118 @default.
• W2473611361 cites W2125985597 @default.
• W2473611361 cites W2162572393 @default.
• W2473611361 cites W2166231028 @default.
• W2473611361 hasPublicationYear "2016" @default.
• W2473611361 type Work @default.
• W2473611361 sameAs 2473611361 @default.
• W2473611361 citedByCount "0" @default.
• W2473611361 crossrefType "journal-article" @default.
• W2473611361 hasAuthorship W2473611361A5033224530 @default.
• W2473611361 hasAuthorship W2473611361A5053715070 @default.
• W2473611361 hasAuthorship W2473611361A5079589829 @default.
• W2473611361 hasAuthorship W2473611361A5082317086 @default.
• W2473611361 hasConcept C126322002 @default.
• W2473611361 hasConcept C142724271 @default.
• W2473611361 hasConcept C204787440 @default.
• W2473611361 hasConcept C27081682 @default.
• W2473611361 hasConcept C2776347271 @default.
• W2473611361 hasConcept C2776451879 @default.
• W2473611361 hasConcept C2777786777 @default.
• W2473611361 hasConcept C2779254346 @default.
• W2473611361 hasConcept C2779904517 @default.
• W2473611361 hasConcept C42972112 @default.
• W2473611361 hasConcept C59822182 @default.
• W2473611361 hasConcept C71924100 @default.
• W2473611361 hasConcept C86803240 @default.
• W2473611361 hasConceptScore W2473611361C126322002 @default.
• W2473611361 hasConceptScore W2473611361C142724271 @default.
• W2473611361 hasConceptScore W2473611361C204787440 @default.
• W2473611361 hasConceptScore W2473611361C27081682 @default.
• W2473611361 hasConceptScore W2473611361C2776347271 @default.
• W2473611361 hasConceptScore W2473611361C2776451879 @default.
• W2473611361 hasConceptScore W2473611361C2777786777 @default.
• W2473611361 hasConceptScore W2473611361C2779254346 @default.
• W2473611361 hasConceptScore W2473611361C2779904517 @default.
• W2473611361 hasConceptScore W2473611361C42972112 @default.
• W2473611361 hasConceptScore W2473611361C59822182 @default.
• W2473611361 hasConceptScore W2473611361C71924100 @default.
• W2473611361 hasConceptScore W2473611361C86803240 @default.
• W2473611361 hasLocation W24736113611 @default.
• W2473611361 hasOpenAccess W2473611361 @default.
• W2473611361 hasPrimaryLocation W24736113611 @default.
• W2473611361 hasRelatedWork W110436171 @default.
• W2473611361 hasRelatedWork W1972560655 @default.
• W2473611361 hasRelatedWork W1975178417 @default.
• W2473611361 hasRelatedWork W2014537421 @default.
• W2473611361 hasRelatedWork W2027093241 @default.
• W2473611361 hasRelatedWork W2276488369 @default.
• W2473611361 hasRelatedWork W2279440187 @default.
• W2473611361 hasRelatedWork W2283900036 @default.
• W2473611361 hasRelatedWork W2287714967 @default.
• W2473611361 hasRelatedWork W2293783944 @default.
• W2473611361 hasRelatedWork W2300900718 @default.
• W2473611361 hasRelatedWork W2315628439 @default.
• W2473611361 hasRelatedWork W2604977003 @default.
• W2473611361 hasRelatedWork W2605056555 @default.
• W2473611361 hasRelatedWork W2765150341 @default.
• W2473611361 hasRelatedWork W2766514631 @default.
• W2473611361 hasRelatedWork W2766557416 @default.
• W2473611361 hasRelatedWork W3000255452 @default.
• W2473611361 hasRelatedWork W3010991442 @default.
• W2473611361 hasRelatedWork W3145769675 @default.
• W2473611361 isParatext "false" @default.
• W2473611361 isRetracted "false" @default.
• W2473611361 magId "2473611361" @default.
• W2473611361 workType "article" @default.