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- W2473622490 abstract "Abstract The importance of spatial organization in short peptide catalysts is well recognized. We synthesized and screened a library of peptides flanked by peptide nucleic acids (PNAs) such that the peptide would be constrained in a hairpin loop upon hybridization. A screen for phosphatase activity led to the discovery of a catalyst with >25‐fold rate acceleration over the linear peptide. We demonstrated that the hybridization‐enforced folding of the peptide is necessary for activity, and designed a catalyst that is allosterically controlled using a complementary PNA sequence." @default.
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- W2473622490 date "2016-06-20" @default.
- W2473622490 modified "2023-09-25" @default.
- W2473622490 title "Allosterically Regulated Phosphatase Activity from Peptide–PNA Conjugates Folded Through Hybridization" @default.
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- W2473622490 doi "https://doi.org/10.1002/anie.201602751" @default.
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