FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2473655105> ?p ?o ?g. }

• W2473655105 abstract "+ T cells and B cells mediate cGVHD; therefore, targeting these populations may inhibit cGVHD pathogenesis. Ibrutinib is an FDA-approved irreversible inhibitor of Bruton's tyrosine kinase (BTK) and IL-2 inducible T cell kinase (ITK) that targets Th2 cells and B cells and produces durable remissions in B cell malignancies with minimal toxicity. Here, we evaluated whether ibrutinib could reverse established cGVHD in 2 complementary murine models, a model interrogating T cell-driven sclerodermatous cGVHD and an alloantibody-driven multiorgan system cGVHD model that induces bronchiolar obliterans (BO). In the T cell-mediated sclerodermatous cGVHD model, ibrutinib treatment delayed progression, improved survival, and ameliorated clinical and pathological manifestations. In the alloantibody-driven cGVHD model, ibrutinib treatment restored pulmonary function and reduced germinal center reactions and tissue immunoglobulin deposition. Animals lacking BTK and ITK did not develop cGVHD, indicating that these molecules are critical to cGVHD development. Furthermore, ibrutinib treatment reduced activation of T and B cells from patients with active cGVHD. Our data demonstrate that B cells and T cells drive cGVHD and suggest that ibrutinib has potential as a therapeutic agent, warranting consideration for cGVHD clinical trials." @default.
• W2473655105 created "2016-07-22" @default.
• W2473655105 creator A5000921376 @default.
• W2473655105 creator A5004776812 @default.
• W2473655105 creator A5007648913 @default.
• W2473655105 creator A5007847102 @default.
• W2473655105 creator A5008015101 @default.
• W2473655105 creator A5008718116 @default.
• W2473655105 creator A5015771825 @default.
• W2473655105 creator A5021564306 @default.
• W2473655105 creator A5026510629 @default.
• W2473655105 creator A5029278364 @default.
• W2473655105 creator A5029390145 @default.
• W2473655105 creator A5037106923 @default.
• W2473655105 creator A5042070203 @default.
• W2473655105 creator A5045561472 @default.
• W2473655105 creator A5048706550 @default.
• W2473655105 creator A5050861419 @default.
• W2473655105 creator A5051145637 @default.
• W2473655105 creator A5054037976 @default.
• W2473655105 creator A5055913041 @default.
• W2473655105 creator A5056327118 @default.
• W2473655105 creator A5056345529 @default.
• W2473655105 creator A5058268746 @default.
• W2473655105 creator A5058556276 @default.
• W2473655105 creator A5062183309 @default.
• W2473655105 creator A5068040261 @default.
• W2473655105 creator A5068050082 @default.
• W2473655105 creator A5071072428 @default.
• W2473655105 creator A5072835425 @default.
• W2473655105 creator A5081366253 @default.
• W2473655105 date "2014-01-01" @default.
• W2473655105 modified "2023-09-24" @default.
• W2473655105 title "Chronic graft-versus-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transplantation, and current therapies do not completely prevent and/or treat cGVHD. CD4" @default.
• W2473655105 cites W118161642 @default.
• W2473655105 cites W1509735873 @default.
• W2473655105 cites W1544331058 @default.
• W2473655105 cites W1801742181 @default.
• W2473655105 cites W1864245546 @default.
• W2473655105 cites W1951217465 @default.
• W2473655105 cites W1964767404 @default.
• W2473655105 cites W1966429220 @default.
• W2473655105 cites W1980841426 @default.
• W2473655105 cites W1982914579 @default.
• W2473655105 cites W1983395516 @default.
• W2473655105 cites W1986690269 @default.
• W2473655105 cites W1990102711 @default.
• W2473655105 cites W1991504720 @default.
• W2473655105 cites W1992729068 @default.
• W2473655105 cites W1995326684 @default.
• W2473655105 cites W2005604237 @default.
• W2473655105 cites W2012262764 @default.
• W2473655105 cites W2014041834 @default.
• W2473655105 cites W2018466312 @default.
• W2473655105 cites W2019419625 @default.
• W2473655105 cites W2028842451 @default.
• W2473655105 cites W2030937557 @default.
• W2473655105 cites W2031549987 @default.
• W2473655105 cites W2034081128 @default.
• W2473655105 cites W2034946023 @default.
• W2473655105 cites W2036749000 @default.
• W2473655105 cites W2037182528 @default.
• W2473655105 cites W2037398046 @default.
• W2473655105 cites W2041548911 @default.
• W2473655105 cites W2042030389 @default.
• W2473655105 cites W2049808194 @default.
• W2473655105 cites W2051858312 @default.
• W2473655105 cites W2055068449 @default.
• W2473655105 cites W2060951143 @default.
• W2473655105 cites W2069308836 @default.
• W2473655105 cites W2071549499 @default.
• W2473655105 cites W2075875145 @default.
• W2473655105 cites W2082167435 @default.
• W2473655105 cites W2086030126 @default.
• W2473655105 cites W2089103836 @default.
• W2473655105 cites W2091347081 @default.
• W2473655105 cites W2103227315 @default.
• W2473655105 cites W2107773259 @default.
• W2473655105 cites W2118392817 @default.
• W2473655105 cites W2143754819 @default.
• W2473655105 cites W2143755862 @default.
• W2473655105 cites W2147922459 @default.
• W2473655105 cites W2154066874 @default.
• W2473655105 cites W2155835218 @default.
• W2473655105 cites W2161578291 @default.
• W2473655105 cites W2162001241 @default.
• W2473655105 cites W2163690533 @default.
• W2473655105 cites W2164349125 @default.
• W2473655105 cites W2164855614 @default.
• W2473655105 cites W2164945798 @default.
• W2473655105 cites W2165090528 @default.
• W2473655105 cites W2169226551 @default.
• W2473655105 cites W2379365975 @default.
• W2473655105 hasPublicationYear "2014" @default.
• W2473655105 type Work @default.
• W2473655105 sameAs 2473655105 @default.
• W2473655105 citedByCount "0" @default.
• W2473655105 crossrefType "journal-article" @default.
• W2473655105 hasAuthorship W2473655105A5000921376 @default.
• W2473655105 hasAuthorship W2473655105A5004776812 @default.

• next