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• W2473660410 abstract "Elevated plasma free fatty acid (FFA) levels are responsible for much of the insulin resistance in obese patients with type 2 diabetes. To lower plasma FFA levels effectively and long term, we have treated eight obese patients with type 2 diabetes for 2 months with placebo followed by 2 months of treatment with a combination of rosiglitazone (RGZ) (8 mg/day) and fenofibrate (FFB) (160 mg/day) in a single-blind placebo-controlled study design. Compared with placebo, RGZ/FFB lowered mean 24-h plasma FFA levels 30% (P &lt; 0.03) and mean 24-h glucose levels 23% (P &lt; 0.03) and increased insulin-stimulated glucose uptake (glucose rate of disappearance [GRd], determined using euglycemic-hyperinsulinemic clamp) 442% (P &lt; 0.01), oral glucose tolerance (area under the curve for 3-h oral glucose tolerance test) 28% (P &lt; 0.05), and plasma adiponectin levels 218% (P &lt; 0.01). These RGZ/FFB results were compared with results obtained in five patients treated with RGZ alone. RGZ/FFB prevented the fluid retention usually associated with RGZ (−1.6 vs. 5.6%, P &lt; 0.05), lowered fasting plasma FFA more effectively than RGZ alone (−22 vs. 5%, P &lt; 0.05), and tended to be more effective than RGZ alone in lowering A1C (−0.9 vs. −0.4%) and triglyceride levels (−38 vs. −5%) and increasing GRd (442 vs. 330%). We conclude that RGZ/FFB is a promising new therapy for type 2 diabetes that lowers plasma FFA more than RGZ alone and in contrast to RGZ does not cause water retention and weight gain." @default.
• W2473660410 created "2016-07-22" @default.
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• W2473660410 date "2007-01-01" @default.
• W2473660410 modified "2023-10-13" @default.
• W2473660410 title "Combined Use of Rosiglitazone and Fenofibrate in Patients With Type 2 Diabetes" @default.
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• W2473660410 doi "https://doi.org/10.2337/db06-0481" @default.
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