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- W2473669551 endingPage "1421" @default.
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- W2473669551 abstract "Natural killer (NK) cells are members of the innate immune system that recognize target cells via activating and inhibitory signals received through cell receptors. Derived from the lymphoid lineage, NK cells are able to produce cytokines and exert a cytotoxic effect on viral infected and malignant cells. It is their unique ability to lyse target cells rapidly and without prior education that renders NK cells a promising effector cell for adoptive cell therapy. However, both viruses and tumors employ evasion strategies to avoid attack by NK cells, which represent biological challenges that need to be harnessed to fully exploit the cytolytic potential of NK cells. Using genetic modification, the function of NK cells can be enhanced to improve their homing, cytolytic activity, in vivo persistence and safety. Examples include gene modification to express chemokine, high-affinity Fc receptor and chimeric antigen receptors, suicide genes and the forced expression of cytokines such as interleukin (IL)-2 and IL-15. Preclinical studies have clearly demonstrated that such approaches are effective in improving NK-cell function, homing and safety. In this review, we summarize the recent advances in the genetic manipulations of NK cells and their application for cellular immunotherapeutic strategies." @default.
- W2473669551 created "2016-07-22" @default.
- W2473669551 creator A5003003191 @default.
- W2473669551 creator A5007896769 @default.
- W2473669551 creator A5014340992 @default.
- W2473669551 creator A5041746704 @default.
- W2473669551 creator A5043243050 @default.
- W2473669551 creator A5057775882 @default.
- W2473669551 creator A5082887496 @default.
- W2473669551 date "2016-11-01" @default.
- W2473669551 modified "2023-10-18" @default.
- W2473669551 title "Improving efficacy of cancer immunotherapy by genetic modification of natural killer cells" @default.
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