FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2473679423> ?p ?o ?g. }

• W2473679423 abstract "Objective: The effects of obstructive azoospermia on the testis and epididymis have been studied in vasectomized subjects. However, effects of obstruction to sperm egress in primary obstructive azoospermia on the testes and epididymis have not been extensively reported. The present study on fifty patients of primary obstructive azoospermia focuses on the local immune response and its effect on the testis and epididymis. This was a prospective study in a tertiary hospital setting comparing epididymal histology and epididymal fluid antisperm antibody in men with primary obstructive infertility with those in men with proven fertility. Material and Methods: Fifty males with primary obstructive infertility in the study group and ten subjects with proven fertility as controls were included in the study. While performing vasoepididymostomy on such patients, testicular and epididymal tissues were taken, and epididymal fluid was aspirated for estimation of antisperm antibodies. Testicular and epididymal histologies were studied under light microscopy for evidence of cellular immune response to obstruction. Antisperm antibodies in epididymal fluid were assayed by ELISA. Result(s): No effects of obstruction were evident on spermatogenesis or the testicular histology. Epididymal epithelial flattening with local or diffuse loss of cilia (n=25); pigment in the epithelial cells as a remnant of sperm ingestion (n=20); intraductal macrophages (n=29) with sperm ingestion in 62%; breach of epithelium with sperm extravasation (n=20) were considered as evidence of effects of obstruction leading to proximal ductal dilatation and damage. Presence of plasma cells and lymphocytes (n=31) and macrophages (n=11) in the interstitium were considered effects of antigenic sperm extravasation in the interstitium. These effects could be a local cell mediated immune response. Significant ELISA for antisperm antibodies was found in 29 patients; all patients with inflammatory cell infiltrate in the interstitium had significant ELISA for antisperm antibodies in the epididymal fluid. The cellular immune response as assessed by the presence of interstitial inflammatory cells and macrophages in epididymal histology was found in 12/20 patients. Testicular biopsies in all patients were normal. Humoral immune response as assessed by significant titres of antisperm antibodies in epididymal fluid was found in 14/20 patients. Evidence of local immune response (cellular or humoral or both) was found in 17/20 patients. Conclusion(s): We believe that intermittent exposure to small amounts of extravasated sperms in the epididymal interstitium would be sufficient to produce a local cell mediated immune response with its attendant effects on the epididymis, the primary site of sperm maturation, producing irreversible changes in its structure." @default.
• W2473679423 created "2016-07-22" @default.
• W2473679423 date "2011-01-01" @default.
• W2473679423 modified "2023-09-26" @default.
• W2473679423 title "Effect Of Obstruction To Sperm Egress On The Male Testis And Epididymis" @default.
• W2473679423 cites W136842601 @default.
• W2473679423 cites W1475884942 @default.
• W2473679423 cites W1502278336 @default.
• W2473679423 cites W1514349234 @default.
• W2473679423 cites W18691634 @default.
• W2473679423 cites W1911238254 @default.
• W2473679423 cites W1913060700 @default.
• W2473679423 cites W1968992221 @default.
• W2473679423 cites W1987932968 @default.
• W2473679423 cites W1996915406 @default.
• W2473679423 cites W2003083549 @default.
• W2473679423 cites W2007183054 @default.
• W2473679423 cites W2013340615 @default.
• W2473679423 cites W2013637129 @default.
• W2473679423 cites W2025645197 @default.
• W2473679423 cites W2035626302 @default.
• W2473679423 cites W2042462992 @default.
• W2473679423 cites W2049108052 @default.
• W2473679423 cites W2057146576 @default.
• W2473679423 cites W2066575701 @default.
• W2473679423 cites W2087802069 @default.
• W2473679423 cites W2089664874 @default.
• W2473679423 cites W2090197669 @default.
• W2473679423 cites W2107855510 @default.
• W2473679423 cites W2131709416 @default.
• W2473679423 cites W2149545578 @default.
• W2473679423 cites W2284461198 @default.
• W2473679423 cites W2298412770 @default.
• W2473679423 cites W2300674167 @default.
• W2473679423 cites W2405192317 @default.
• W2473679423 cites W2409932794 @default.
• W2473679423 cites W2410098510 @default.
• W2473679423 cites W2411731609 @default.
• W2473679423 cites W2463944022 @default.
• W2473679423 cites W2503617805 @default.
• W2473679423 doi "https://doi.org/10.5580/11dc" @default.
• W2473679423 hasPublicationYear "2011" @default.
• W2473679423 type Work @default.
• W2473679423 sameAs 2473679423 @default.
• W2473679423 citedByCount "0" @default.
• W2473679423 crossrefType "journal-article" @default.
• W2473679423 hasConcept C126322002 @default.
• W2473679423 hasConcept C16685009 @default.
• W2473679423 hasConcept C2781087480 @default.
• W2473679423 hasConcept C2781254305 @default.
• W2473679423 hasConcept C2992926266 @default.
• W2473679423 hasConcept C71924100 @default.
• W2473679423 hasConceptScore W2473679423C126322002 @default.
• W2473679423 hasConceptScore W2473679423C16685009 @default.
• W2473679423 hasConceptScore W2473679423C2781087480 @default.
• W2473679423 hasConceptScore W2473679423C2781254305 @default.
• W2473679423 hasConceptScore W2473679423C2992926266 @default.
• W2473679423 hasConceptScore W2473679423C71924100 @default.
• W2473679423 hasIssue "1" @default.
• W2473679423 hasLocation W24736794231 @default.
• W2473679423 hasOpenAccess W2473679423 @default.
• W2473679423 hasPrimaryLocation W24736794231 @default.
• W2473679423 hasRelatedWork W1969242820 @default.
• W2473679423 hasRelatedWork W2012771026 @default.
• W2473679423 hasRelatedWork W2044807331 @default.
• W2473679423 hasRelatedWork W2086560894 @default.
• W2473679423 hasRelatedWork W2121876825 @default.
• W2473679423 hasRelatedWork W2187382732 @default.
• W2473679423 hasRelatedWork W2560723143 @default.
• W2473679423 hasRelatedWork W2789688840 @default.
• W2473679423 hasRelatedWork W3131902880 @default.
• W2473679423 hasRelatedWork W3157450805 @default.
• W2473679423 hasVolume "8" @default.
• W2473679423 isParatext "false" @default.
• W2473679423 isRetracted "false" @default.
• W2473679423 magId "2473679423" @default.
• W2473679423 workType "article" @default.